ArticleJournal of virology1996
Gene transfer into mammalian cells by a Rous sarcoma virus-based retroviral vector with the host range of the amphotropic murine leukemia virus.
Article in Journal of virology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 47 citations in OpenAlex.
- Alpharetroviral vectors: from a cancer-causing agent to a useful tool for human gene therapy.Viruses · 2014Review
- Use of lentiviral vectors to deliver and express bicistronic transgenes in developing chicken embryos.Methods (San Diego, Calif.) · 2014Article
- Alpharetroviral vector-mediated gene therapy for X-CGD: functional correction and lack of aberrant splicing.Molecular therapy : the journal of the American Society of Gene Therapy · 2013Article
- Retroviral DNA methylation and epigenetic repression are mediated by the antiviral host protein Daxx.Journal of virology · 2013Article
- Retroviral replicating vectors in cancer.Methods in enzymology · 2012Article
- Modification of integration site preferences of an HIV-1-based vector by expression of a novel synthetic protein.Human gene therapy · 2010Article
- The core element of a CpG island protects avian sarcoma and leukosis virus-derived vectors from transcriptional silencing.Journal of virology · 2008Article
- Identification of cellular proteins that maintain retroviral epigenetic silencing: evidence for an antiviral response.Journal of virology · 2008Article
- Transgene expression facilitated by the v-src splice acceptor can impair replication kinetics and lead to genomic instability of Rous sarcoma virus-based vectors.Journal of virology · 2008Article
- High-frequency epigenetic repression and silencing of retroviruses can be antagonized by histone deacetylase inhibitors and transcriptional activators, but uniform reactivation in cell clones is restricted by additional mechanisms.Journal of virology · 2007Article
- Mutations of a residue within the polyproline-rich region of Env alter the replication rate and level of cytopathic effects in chimeric avian retroviral vectors.Journal of virology · 2005Article
- Genome-wide analyses of avian sarcoma virus integration sites.Journal of virology · 2004Article
- Delivery of short hairpin RNA sequences by using a replication-competent avian retroviral vector.Journal of virology · 2004Article
- Transduction of terminally differentiated neurons by avian sarcoma virus.Journal of virology · 2004Article
- Transduction of interphase cells by avian sarcoma virus.Journal of virology · 2002Article
- Genomic stability of murine leukemia viruses containing insertions at the Env-3' untranslated region boundary.Journal of virology · 2001Article
- Adaptation of chimeric retroviruses in vitro and in vivo: isolation of avian retroviral vectors with extended host range.Journal of virology · 2001Article
- Wortmannin potentiates integrase-mediated killing of lymphocytes and reduces the efficiency of stable transduction by retroviruses.Molecular and cellular biology · 2001Article
- An avian sarcoma/leukosis virus-based gene trap vector for mammalian cells.Journal of virology · 1999Article
- Replication-competent chimeric lenti-oncovirus with expanded host cell tropism.Journal of virology · 1997Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have constructed and characterized a Rous sarcoma virus-based retroviral vector with the host range of the amphotropic murine leukemia virus (MLV). The chimeric retroviral genome was created by replacing the env coding region in the replication-competent retroviral vector RCASBP(A) with the env region from an amphotropic MLV. The recombinant vector RCASBP-M(4070A) forms particles containing MLV Env glycoproteins. The vector replicates efficiently in chicken embryo fibroblasts and is able to transfer genes into mammalian cells. Vector stocks with titers exceeding 10(6) CFU/ml on mammalian cells can be easily prepared by passaging transfected chicken embryo fibroblasts. Since the vector is inherently defective in mammalian cells, it appears to have the safety features required for gene therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.