ArticleJournal of virology1996
The human foamy virus Bel-1 transcription factor is a sequence-specific DNA binding protein.
Article in Journal of virology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 60 citations in OpenAlex.
- SAP30 deacetylates the Tas protein to inhibit PFV replication.Cell & bioscience · 2025Article
- ZNF219, a novel transcriptional repressor, inhibits transcription of the prototype foamy virus by interacting with the viral LTR promoter.Virus research · 2023Article
- SGK1, a Serine/Threonine Kinase, Inhibits Prototype Foamy Virus Replication.Microbiology spectrum · 2022Article
- Trim28 acts as restriction factor of prototype foamy virus replication by modulating H3K9me3 marks and destabilizing the viral transactivator Tas.Retrovirology · 2021Article
- Nuclear import of prototype foamy virus transactivator Bel1 is mediated by KPNA1, KPNA6 and KPNA7.International journal of molecular medicine · 2016Article
- Important role of N108 residue in binding of bovine foamy virus transactivator Tas to viral promoters.Virology journal · 2016Article
- Review
- Non-simian foamy viruses: molecular virology, tropism and prevalence and zoonotic/interspecies transmission.Viruses · 2013Review
- Genetic characterization of simian foamy viruses infecting humans.Journal of virology · 2012Article
- A new indicator cell line established to monitor bovine foamy virus infection.Virologica Sinica · 2011Article
- Review
- Molecular biology of foamy viruses.Medical microbiology and immunology · 2010Review
- IFP35 is involved in the antiviral function of interferon by association with the viral tas transactivator of bovine foamy virus.Journal of virology · 2008Article
- Human foamy virus bel1 sequence in patients with autoimmune rheumatic diseases.Clinical rheumatology · 2006Article
- Coactivators p300 and PCAF physically and functionally interact with the foamy viral trans-activator.BMC molecular biology · 2004Article
- The promyelocytic leukemia protein does not mediate foamy virus latency in vitro.Journal of virology · 2003Article
- Reactivation of a complex retrovirus is controlled by a molecular switch and is inhibited by a viral protein.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Further characterization of equine foamy virus reveals unusual features among the foamy viruses.Journal of virology · 2002Article
- Intra- and intercellular trafficking of the foamy virus auxiliary bet protein.Journal of virology · 2002Article
- Improved primate foamy virus vectors and packaging constructs.Journal of virology · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Bel-1 transcriptional transactivator encoded by human foamy virus (HFV) can efficiently activate gene expression directed by both the HFV long terminal repeat (LTR) and internal (Int) promoter elements. By DNA footprinting and gel retardation analysis, we demonstrate that Bel-1 can specifically bind to discrete sites in both the LTR and Int promoter elements in vitro. However, transactivation of the HFV LTR by Bel-1 was observed to require not only the promoter-proximal Bel-1 binding site identified in vitro but also additional promoter-distal sequences. These data suggest that Bel-1 binding is necessary but not sufficient for efficient transactivation of Bel-1-responsive promoters in mammalian cells and therefore raise the possibility that Bel-1 function may require the action of a cellular DNA binding protein(s). Importantly, these data demonstrate that Bel-1 is unique among retroviral regulatory proteins in being a sequence-specific DNA binding protein.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.