ArticleJournal of virology1996
Quantitative model of antibody- and soluble CD4-mediated neutralization of primary isolates and T-cell line-adapted strains of human immunodeficiency virus type 1.
Article in Journal of virology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed.
- Glycan heterogeneity as a cause of the persistent fraction in HIV-1 neutralization.PLoS pathogens · 2023Article
- Closing and Opening Holes in the Glycan Shield of HIV-1 Envelope Glycoprotein SOSIP Trimers Can Redirect the Neutralizing Antibody Response to the Newly Unmasked Epitopes.Journal of virology · 2019Article
- Dense Array of Spikes on HIV-1 Virion Particles.Journal of virology · 2017Article
- Predicting HIV-1 transmission and antibody neutralization efficacy in vivo from stoichiometric parameters.PLoS pathogens · 2017Article
- Characterization of anti-porcine epidemic diarrhea virus neutralizing activity in mammary secretions.Virus research · 2016Article
- Quantitative Correlation between Infectivity and Gp120 Density on HIV-1 Virions Revealed by Optical Trapping Virometry.The Journal of biological chemistry · 2016Article
- Short Communication: Virion Aggregation by Neutralizing and Nonneutralizing Antibodies to the HIV-1 Envelope Glycoprotein.AIDS research and human retroviruses · 2015Article
- Molecular determinants of the ratio of inert to infectious virus particles.Progress in molecular biology and translational science · 2015Review
- Translocalized IgA mediates neutralization and stimulates innate immunity inside infected cells.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunits.Retrovirology · 2014Article
- Equilibrium and kinetics of Sin Nombre hantavirus binding at DAF/CD55 functionalized bead surfaces.Viruses · 2014Article
- The Fc region of an antibody impacts the neutralization of West Nile viruses in different maturation states.Journal of virology · 2013Article
- Rapid parallel flow cytometry assays of active GTPases using effector beads.Analytical biochemistry · 2013Article
- The molecular basis of HIV entry.Cellular microbiology · 2012Review
- Regulation of virus neutralization and the persistent fraction by TRIM21.Journal of virology · 2012Article
- Article
- Induction of antibody-mediated neutralization in SIVmac239 by a naturally acquired V3 mutation.Virology · 2010Article
- Antibody-mediated synergy and interference in the neutralization of SARS-CoV at an epitope cluster on the spike protein.Biochemical and biophysical research communications · 2009Article
- Heavily isotype-dependent protective activities of human antibodies against vaccinia virus extracellular virion antigen B5.Journal of virology · 2009Article
- Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Primary isolates (PI) of human immunodeficiency virus type 1 (HIV-1) are considerably less sensitive than T-cell line-adapted strains to neutralization by soluble CD4 and by most cross-reactive monoclonal antibodies to the viral envelope (Env) glycoprotein, as well as by postinfection and postvaccination sera (J. P. Moore and D. D. Ho, AIDS 9 [suppl. A]:5117-5136, 1995). We developed a quantitative model to explain the neutralization resistance of PI. The factors incorporated into the model are the dissociation constants for the binding of the neutralizing agent to native Env oligomers, the number of outer Env molecules on the viral surface (which decreases by shedding), and the minimum number of Env molecules required for attachment and fusion. We conclude that modest differences in all these factors can, when combined, explain a relative neutralization resistance of PI versus T-cell line-adapted strains that sometimes amounts to several orders of magnitude. The hypothesis that neutralization of HIV is due to the reduction below a minimum number of the Env molecules on a virion available for attachment and fusion is at odds with single- and few-hit neutralization theories. Our analysis of these ideas favors the hypothesis that neutralization of HIV is instead a competitive blocking of interactions with cellular factors, including adsorption receptors.
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