ArticleJournal of neurology, neurosurgery, and psychiatry1996
Peripheral neuropathy associated with essential mixed cryoglobulinaemia: a role for hepatitis C virus infection?
Article in Journal of neurology, neurosurgery, and psychiatry, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 101 citations in OpenAlex.
- Hepatitis C-related cryoglobulinemic neuropathy: potential role of oxcarbazepine for pain control.BMC gastroenterology · 2018Article
- Sofosbuvir-daclatasvir improves hepatitis C virus-induced mixed cryoglobulinemia: Upper Egypt experience.Infection and drug resistance · 2018Article
- Screening for Electrophysiological Abnormalities in Chronic Hepatitis C Infection: Peripheral Neuropathy and Optic Neuropathy.Noro psikiyatri arsivi · 2016Article
- Sensory neuropathy in patients with cryoglobulin negative hepatitis-C infection.Journal of neurology · 2011Article
- Multifocal central and peripheral demyelination associated with hepatitis C virus infection.Journal of neurology · 2007Article
- Immunohistochemical detection of HCV in nerves and muscles of patients with HCV associated peripheral neuropathy and myositis.International journal of health sciences · 2007Article
- Prevalence and characteristics of peripheral neuropathy in hepatitis C virus population.Journal of neurology, neurosurgery, and psychiatry · 2006Article
- Clinical spectrum of cryoglobulinaemic neuropathy.Journal of neurology, neurosurgery, and psychiatry · 2005Article
- Hepatitis C virus-associated extrahepatic manifestations: a review.Metabolic brain disease · 2004Review
- [Vasculitis associated with viral infections].Presse medicale (Paris, France : 1983) · 2004Review
- Peripheral neuropathy in hepatitis C virus infection with and without cryoglobulinaemia.Journal of neurology, neurosurgery, and psychiatry · 2003Article
- Paraproteinemic Neuropathy.Current treatment options in neurology · 2001Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe prevalence of hepatitis C virus (HCV) infection has been estimated at 43 to 84% in patients with essential mixed cryoglobulinaemia in recent large series. Some of these cases have been successfully treated with interferon-alpha. The objective was to evaluate the prevalence and the possible role of HCV infection in essential mixed cryoglobulinaemia.
methodsFifteen patients (eight men and seven women; mean age: 61.2 (SD 16.5) years) with peripheral neuropathy (10 polyneuropathies and five multifocal mononeuropathies) and essential mixed cryoglobulinaemia were tested for serum anti-HCV antibodies.
resultsAntibodies were found in 10 of 15 patients involving either polyneuropathies (seven patients) or multifocal mononeuropathies (three patients). Electrophysiological studies and teased nerve fibre studies (in seven patients) allowed neuropathies to be classified as predominantly sensory axonopathies. Compared with HCV-negative (HCV -) patients, HCV-positive (HCV +) patients had a more pronounced and more widespread motor deficit; motor nerve conduction velocities in peroneal and median nerves were more impaired in HCV + patients, although significance was not reached except for the mean value of the amplitude of the compound muscle action potentials of the median nerves (P < 0.05); necrotising vasculitis was found in two of nine nerve biopsies from the HCV + patients studied and in none of the three HCV - patients. In addition, HCV + patients had more frequent cryoglobulin related cutaneous signs, higher aminotransferase and serum cryoglobulin concentrations, lower total haemolytic complement concentrations, and more frequent presence of rheumatoid factor. A liver biopsy performed in eight HCV + patients disclosed a range of lesions, from chronic active hepatitis (six patients) to persistent hepatitis (two patients). Lastly, treatment with interferon-alpha conducted over six months in two patients seemed to improve the peripheral neuropathy.
conclusionsPatients with peripheral neuropathy and essential mixed cryoglobulinaemia should be tested for anti-HCV antibodies to determine the appropriate treatment.
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