ArticleThe Journal of clinical investigation1996
Molecular cloning of a glibenclamide-sensitive, voltage-gated potassium channel expressed in rabbit kidney.
Article in The Journal of clinical investigation, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 58 citations in OpenAlex.
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- The impact of sulfonylureas on diverse ion channels: an alternative explanation for the antidiabetic actions.Frontiers in cell and developmental biology · 2025Review
- Regulation of myocardial oxygen delivery in response to graded reductions in hematocrit: role of KBasic research in cardiology · 2017Article
- Kv1.3 channels facilitate the connection between metabolism and blood flow in the heart.Microcirculation (New York, N.Y. : 1994) · 2017Review
- Requisite Role of Kv1.5 Channels in Coronary Metabolic Dilation.Circulation research · 2015Article
- Systemic Administration of Glibenclamide Fails to Achieve Therapeutic Levels in the Brain and Cerebrospinal Fluid of Rodents.PloS one · 2015Article
- Serum- and glucocorticoid-inducible kinase 1 in the regulation of renal and extrarenal potassium transport.Clinical and experimental nephrology · 2012Review
- Voltage-gated potassium channel Kv1.3 blocker as a potential treatment for rat anti-glomerular basement membrane glomerulonephritis.American journal of physiology. Renal physiology · 2010Article
- Contribution of adenosine A(2A) and A(2B) receptors to ischemic coronary dilation: role of K(V) and K(ATP) channels.Microcirculation (New York, N.Y. : 1994) · 2010Article
- Potassium secretion by voltage-gated potassium channel Kv1.3 in the rat kidney.American journal of physiology. Renal physiology · 2010Article
- Inhibition of phosphatidylinositol 3-kinase stimulates activity of the small-conductance K channel in the CCD.American journal of physiology. Renal physiology · 2006Article
- Molecular diversity and regulation of renal potassium channels.Physiological reviews · 2005Review
- The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Protein kinase C (PKC)-induced phosphorylation of ROMK1 is essential for the surface expression of ROMK1 channels.The Journal of biological chemistry · 2002Article
- Hydrophobic free energy eigenfunctions of pore, channel, and transporter proteins contain beta-burst patterns.Biophysical journal · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Shaker genes encode voltage-gated potassium channels (Kv). We have shown previously that genes from Shaker subfamilies Kv1.1, 1.2, 1.4 are expressed in rabbit kidney. Recent functional and molecular evidence indicate that the predominant potassium conductance of the kidney medullary cell line GRB-PAP1 is composed of Shaker-like potassium channels. We now report the molecular cloning and functional expression of a new Shaker-related voltage-gated potassium channel, rabKv1.3, that is expressed in rabbit brain and kidney medulla. The protein, predicted to be 513 amino acids long, is most closely related to the Kv1.3 family although it differs significantly from other members of that family at the amino terminus. In Xenopus oocytes, rabKv1.3 cRNA expresses a voltage activated K current with kinetic characteristics similar to other members of the Kv1.3 family. However, unlike previously described Shaker channels, it is sensitive to glibenclamide and its single channel conductance saturates. This is the first report of the functional expression of a voltage-gated K channel clone expressed in kidney. We conclude that rabKv1.3 is a novel member of the Shaker superfamily that may play an important role in renal potassium transport.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.