ArticleThe Biochemical journal1996
Sphingolipid metabolites differentially regulate extracellular signal-regulated kinase and stress-activated protein kinase cascades.
Article in The Biochemical journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 106 citations in OpenAlex.
- Clinical application of ceramide in cancer treatment.Breast cancer (Tokyo, Japan) · 2019Review
- Evolving concepts in cancer therapy through targeting sphingolipid metabolism.Biochimica et biophysica acta · 2014Review
- Sphingolipids: regulators of crosstalk between apoptosis and autophagy.Journal of lipid research · 2013Review
- Metronomic ceramide analogs inhibit angiogenesis in pancreatic cancer through up-regulation of caveolin-1 and thrombospondin-1 and down-regulation of cyclin D1.Neoplasia (New York, N.Y.) · 2012Article
- Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis.The Journal of biological chemistry · 2012Article
- Ceramide in stress response.Advances in experimental medicine and biology · 2010Review
- Implication of ceramide, ceramide 1-phosphate and sphingosine 1-phosphate in tumorigenesis.Translational oncogenomics · 2008Article
- Apoptotic effects of dietary and synthetic sphingolipids in androgen-independent (PC-3) prostate cancer cells.Lipids · 2008Article
- Human placental lipid induces mitogenesis and melanogenesis in B16F10 melanoma cells.Journal of biosciences · 2002Article
- TNF ligands and receptors--a matter of life and death.British journal of pharmacology · 2002Review
- Review
- Generation of ceramide in murine macrophages infected with Leishmania donovani alters macrophage signaling events and aids intracellular parasitic survival.Molecular and cellular biochemistry · 2001Article
- Sphingosine 1-phosphate signalling in mammalian cells.The Biochemical journal · 2000Review
- Regulation of mitogen-activated protein kinases by sphingolipid products in oligodendrocytes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Sphingolipids and cell signalling.Journal of inherited metabolic disease · 1998Review
- Distinct pathways for tumor necrosis factor alpha and ceramides in human cytomegalovirus infection.Journal of virology · 1998Article
- Involvement of sphingosine 1-phosphate in nerve growth factor-mediated neuronal survival and differentiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mitogen-activated protein kinase (MAPK) signalling pathway serves to translocate information from activated plasma-membrane receptors to initiate nuclear transcriptional events. This cascade has recently been subdivided into two analogous pathways: the extracellular signal-regulated kinase (ERK) cascade, which preferentially signals mitogenesis, and the stress-activated protein kinase (SAPK) cascade, which is linked to growth arrest and/or cellular inflammation. In concurrent experiments utilizing rat glomerular mesangial cells (MCs), we demonstrate that growth factors or sphingosine activate ERK but not SAPK. In contrast, inflammatory cytokines or cell-permeable ceramide analogues activate SAPK but not ERK. Ceramide, but not sphingosine, induces interleukin-6 secretion, a marker of an inflamed phenotype. Moreover, ceramide can suppress growth factor- or sphingosine-induced ERK activation as well as proliferation. These studies implicate sphingolipid metabolites as opposing regulators of cell proliferation and inflammation through activation of separate kinase cascades.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.