ArticleThe Biochemical journal1996
Tissue specific and androgen-regulated expression of human prostate-specific transglutaminase.
Article in The Biochemical journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 70 citations in OpenAlex.
- Integrated transcriptomic and metabolomic analysis of the hypothalamic-pituitary-testicular axis in rooster lines with contrasting hatchability.Poultry science · 2026Article
- The Evolution of Transglutaminases Underlies the Origin and Loss of Cornified Skin Appendages in Vertebrates.Molecular biology and evolution · 2024Article
- TGM4: an immunogenic prostate-restricted antigen.Journal for immunotherapy of cancer · 2021Article
- Male-derived copulatory plugs enhance implantation success in female Mus musculus.Biology of reproduction · 2021Article
- Search for Novel Diagnostic Biomarkers of Prostate Inflammation-Related Disorders: Role of Transglutaminase Isoforms as Potential Candidates.Mediators of inflammation · 2019Review
- Aminopeptidase activities as prospective urinary biomarkers for bladder cancer.Proteomics. Clinical applications · 2014Article
- Massively parallel sequencing of human urinary exosome/microvesicle RNA reveals a predominance of non-coding RNA.PloS one · 2014Article
- Overexpression of transglutaminase 4 and prostate cancer progression: a potential predictor of less favourable outcomes.Asian journal of andrology · 2013Article
- Genetic disruption of the copulatory plug in mice leads to severely reduced fertility.PLoS genetics · 2013Article
- Retinoic acid and androgen receptors combine to achieve tissue specific control of human prostatic transglutaminase expression: a novel regulatory network with broader significance.Nucleic acids research · 2012Article
- Vena cava and aortic smooth muscle cells express transglutaminases 1 and 4 in addition to transglutaminase 2.American journal of physiology. Heart and circulatory physiology · 2012Article
- Differential alternative splicing of human transglutaminase 4 in benign prostate hyperplasia and prostate cancer.Experimental & molecular medicine · 2010Article
- Tissue transglutaminase, protein cross-linking and Alzheimer's disease: review and views.International journal of clinical and experimental pathology · 2008Article
- Androgen-regulated genes differentially modulated by the androgen receptor coactivator L-dopa decarboxylase in human prostate cancer cells.Molecular cancer · 2007Article
- Use of the PSA enhancer core element to modulate the expression of prostate- and non-prostate-specific basal promoters in a lentiviral vector context.Cancer gene therapy · 2006Article
- Evolution of the hominoid semenogelin genes, the major proteins of ejaculated semen.Journal of molecular evolution · 2003Article
- Two new loci for autosomal recessive ichthyosis on chromosomes 3p21 and 19p12-q12 and evidence for further genetic heterogeneity.American journal of human genetics · 2000Article
- Prediction of gene function by genome-scale expression analysis: prostate cancer-associated genes.Genome research · 1999Article
- Clinical usefulness of RT-PCR detection of hematogenous prostate cancer spread.Urological research · 1997Review
- Spermatozoa protein alterations in infertile men with bilateral varicocele.Asian journal of andrologyArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transglutaminases (TGases) are calcium-dependent enzymes catalysing the post-translational cross-linking of proteins. In the prostate at least two TGases are present, the ubiquitously expressed tissue-type TGase (TGC), and a prostate-restricted TGase (TGP). This paper deals with the molecular cloning and characterization of the cDNA encoding the human prostate TGase (hTGP). For this purpose we have screened a human prostate cDNA library with a probe from the active-site region of TGC. The largest isolated cDNA contained an open reading frame encoding a protein of 684 amino acids with a predicted molecular mass of 77 kDa as confirmed by in vitro transcription-translation and subsequent SDS/PAGE. The hTGP gene was tissue-specifically expressed in the prostate, yielding an mRNA of approx. 3.5 kb. Furthermore, a 3-fold androgen-induced upregulation of hTGP mRNA expression has been demonstrated in the recently developed human prostate cancer cell line, PC346C. Other well established human prostate cancer cell lines, LNCaP and PC-3, showed no detectable hTGP mRNA expression on a Northern bolt. The gene coding for prostate TGase was assigned to chromosome 3.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.