ArticleThe Biochemical journal1996
Regulation of gene expression for translation initiation factor eIF-2 alpha: importance of the 3' untranslated region.
Article in The Biochemical journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 55 citations in OpenAlex.
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- Modulators of MicroRNA Function in the Immune System.International journal of molecular sciences · 2020Review
- Androgen-dependent alternative mRNA isoform expression in prostate cancer cells.F1000Research · 2018Article
- The organization and regulation of mRNA-protein complexes.Wiley interdisciplinary reviews. RNA · 2017Review
- Knockdown of NAT12/NAA30 reduces tumorigenic features of glioblastoma-initiating cells.Molecular cancer · 2015Article
- Global analyses of the effect of different cellular contexts on microRNA targeting.Molecular cell · 2014Article
- Exercise-induced changes of MCT1 in cardiac and skeletal muscles of diabetic rats induced by high-fat diet and STZ.Journal of physiology and biochemistry · 2013Article
- Cross-platform expression microarray performance in a mouse model of mitochondrial disease therapy.Molecular genetics and metabolism · 2010Article
- Article
- Novel Pol II fusion promoter directs human immunodeficiency virus type 1-inducible coexpression of a short hairpin RNA and protein.Journal of virology · 2006Article
- Elevated methyl-CpG-binding protein 2 expression is acquired during postnatal human brain development and is correlated with alternative polyadenylation.Journal of molecular medicine (Berlin, Germany) · 2003Article
- The regulation of protein synthesis and translation factors by CD3 and CD28 in human primary T lymphocytes.BMC biochemistry · 2002Article
- Detection of early gene expression changes during activation of human primary lymphocytes by in vitro synthesis of proteins from polysome-associated mRNAs.Protein science : a publication of the Protein Society · 2001Article
- A GG nucleotide sequence of the 3' untranslated region of amyloid precursor protein mRNA plays a key role in the regulation of translation and the binding of proteins.Molecular and cellular biology · 2000Article
- Immunosuppressants FK506 and rapamycin have different effects on the biosynthesis of cytoplasmic actin during the early period of T cell activation.The Biochemical journal · 1999Article
- The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation.The Biochemical journal · 1999Review
- Lactate transport in skeletal muscle - role and regulation of the monocarboxylate transporter.The Journal of physiology · 1999Review
- Human stearoyl-CoA desaturase: alternative transcripts generated from a single gene by usage of tandem polyadenylation sites.The Biochemical journal · 1999Article
- Universal conservation in translation initiation revealed by human and archaeal homologs of bacterial translation initiation factor IF2.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Alternative poly(A) site selection in complex transcription units: means to an end?Nucleic acids research · 1997Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene expression of the alpha-subunit of eukaryotic initiation factor-2 (eIF-2 alpha), involves transcriptional and post-transcriptional mechanisms. eIF-2 alpha is a single-copy gene expressing two mRNAs, 1.6 and 4.2 kb in size. Cloning and sequencing of the cDNA for the 4.2 kb mRNA revealed that it is the result of alternative polyadenylation site selection. Four polyadenylation sites were identified within the 3' untranslated region (UTR) of eIF-2 alpha, only two of which are normally utilized in human and mouse tissues. A functional role for the extended 3' UTR was assessed by comparing the translatability and stability of the 1.6 and 4.2 kb mRNAs. Both the 1.6 and 4.2 kb transcripts could be translated in vitro and were identified in vivo as being distributed on large polyribosomes. This indicates that both mRNAs are efficiently translated. Stability studies showed that in activated T-cells the 4.2 kb mRNA was more stable than the 1.6 kb mRNA. Polyadenylation site selection and mRNA stability differ for the two mRNAs of eIF-2 alpha. These activities might be modulated by sequence elements contained within the untranslated regions of the eIF-2 alpha gene.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.