ArticleArchives of virology1996
Human rotavirus VP4 contains strain-specific, serotype-specific and cross-reactive neutralization sites.
Article in Archives of virology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Cross-neutralization and antigenic characterization of simian and equine group A rotaviruses.Journal of virology · 2026Article
- Development of Stable Rotavirus Reporter Expression Systems.Journal of virology · 2019Article
- Multiple Introductions and Antigenic Mismatch with Vaccines May Contribute to Increased Predominance of G12P[8] Rotaviruses in the United States.Journal of virology · 2019Article
- Characterization of a G1P[8] rotavirus causing an outbreak of gastroenteritis in the Northern Territory, Australia, in the vaccine era.Emerging microbes & infections · 2014Article
- Identification of novel Ghanaian G8P[6] human-bovine reassortant rotavirus strain by next generation sequencing.PloS one · 2014Article
- Genetic analysis of G12P[8] rotaviruses detected in the largest U.S. G12 genotype outbreak on record.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2014Article
- High-resolution molecular and antigen structure of the VP8* core of a sialic acid-independent human rotavirus strain.Journal of virology · 2006Article
- pH-induced conformational change of the rotavirus VP4 spike: implications for cell entry and antibody neutralization.Journal of virology · 2005Article
- Fine mapping of sequential neutralization epitopes on the subunit protein VP8 of human rotavirus.The Biochemical journal · 2003Article
- The rhesus rotavirus VP4 sialic acid binding domain has a galectin fold with a novel carbohydrate binding site.The EMBO journal · 2002Article
- Rotavirus strain diversity in Blantyre, Malawi, from 1997 to 1999.Journal of clinical microbiology · 2001Article
- Attachment and growth of human rotaviruses RV-3 and S12/85 in Caco-2 cells depend on VP4.Journal of virology · 1998Article
- Serotype specificity of the neutralizing-antibody response induced by the individual surface proteins of rotavirus in natural infections of young children.Clinical and diagnostic laboratory immunology · 1998Article
- Comparison of enzyme immunoassay, PCR, and type-specific cDNA probe techniques for identification of group A rotavirus gene 4 types (P types).Journal of clinical microbiology · 1997Article
- G3P2 rotaviruses causing diarrhoeal disease in neonates differ in VP4, VP7 and NSP4 sequence from G3P2 strains causing asymptomatic neonatal infection.Archives of virology · 1996Article
- Rotavirus typing methods and algorithms.Reviews in medical virologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neutralization epitopes of human rotavirus VP4 were studied by using a panel of neutralization monoclonal antibodies previously shown to be strain-specific (RV-3:3), serotype-specific (RV-5:2, ST-3:3) or cross-reactive (F45:4). Antigenic variants of human rotaviruses RV-3, ST-3, RV-5 and F45 resistant to neutralization by the appropriate of VP4 specific monoclonal antibodies (RV-3:3, ST-3:3, RV-5:2 and F45:4 respectively) were selected. By nucleotide sequence analysis and single strand conformational polymorphism analysis of these variants, three sites of neutralization on VP5* and one site on VP8* were identified. At or near to the putative fusion region on VP5*, a strain-specific site (aa383), a serotype P1A-P2 cross-reactive site (aa392) and a serotype P2-specific site (aa397) were found. On VP8*, a serotype P1B-specific site at aa148 was detected. These results confirmed the importance of the putative fusion region in neutralization and have identified a new neutralization site in the hypervariable region of VP8* which is specific for serotype P1B human rotaviruses.
Indexed as
Identifiers
8645097What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.