Trial reportAnnals of surgery1996
Beta-blockade lowers peripheral lipolysis in burn patients receiving growth hormone. Rate of hepatic very low density lipoprotein triglyceride secretion remains unchanged.
Trial report in Annals of surgery, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 109 citations in OpenAlex.
- Recombinant human growth hormone for treating burns and donor sites.The Cochrane database of systematic reviews · 2014Pooled it
- Metabolic implications of severe burn injuries and their management: a systematic review of the literature.World journal of surgery · 2008Pooled it
- Reduced Postburn Hypertrophic Scarring and Improved Physical Recovery With Yearlong Administration of Oxandrolone and Propranolol.Annals of surgery · 2018Trial
- Long-term propranolol use in severely burned pediatric patients: a randomized controlled study.Annals of surgery · 2012Trial
- Growth hormone treatment in pediatric burns: a safe therapeutic approach.Annals of surgery · 1998Trial
- Insulin therapy in burn patients does not contribute to hepatic triglyceride production.The Journal of clinical investigation · 1998Trial
- Study on metabolic disorders in rat liver induced by different times after scalds.Biochemistry and biophysics reports · 2025Article
- The impact of catecholamines on skeletal muscle following massive burns: Friend or foe?Burns : journal of the International Society for Burn Injuries · 2021Review
- Advanced age heightens hepatic damage in a murine model of scald burn injury.The journal of trauma and acute care surgery · 2021Article
- Burn trauma disrupts circadian rhythms in rat liver.International journal of burns and trauma · 2016Article
- Progress in burns research: a review of advances in burn pathophysiology.Annals of burns and fire disasters · 2015Article
- Burns: an update on current pharmacotherapy.Expert opinion on pharmacotherapy · 2012Review
- Role of β-adrenergic receptors in regulation of hepatic fat accumulation during aging.The Journal of endocrinology · 2012Article
- What, how, and how much should patients with burns be fed?The Surgical clinics of North America · 2011Review
- Association between dietary fat content and outcomes in pediatric burn patients.The Journal of surgical research · 2011Article
- The hypermetabolic response to burn injury and interventions to modify this response.Clinics in plastic surgery · 2009Review
- Modulation of the hypermetabolic response to trauma: temperature, nutrition, and drugs.Journal of the American College of Surgeons · 2009Article
- Nutritional and Pharmacological Modulation of the Metabolic Response of Severely Burned Patients: Review of the Literature (Part II)*.Annals of burns and fire disasters · 2008Article
- The use of beta-adrenergic blockade in preventing trauma-induced hepatomegaly.Annals of surgery · 2006Article
- Insulin treatment improves the systemic inflammatory reaction to severe trauma.Annals of surgery · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe purpose of this study was to determine the effect of propranolol on peripheral lipolysis in massively burned children during treatment with recombinant human growth hormone (rhGH), and to ascertain whether decreased free fatty acid availability for re-esterification would alter the hepatic rate of secretion of triglycerides (TGs) bound to very low density lipoproteins (VLDLs).
backgroundFatty liver occurs in severely burned patients, often resulting in a twofold increase in liver size. This could be the result of an imbalance between increased provision of free fatty acids from peripheral lipolysis, coupled with no increase in fat oxidation, and insufficient rate of secretion of TGs from the liver.
methodsIn a cross-over study, six burned children were treated with either rhGH or rhGH plus propranolol. On the sixth day of treatment, isotopic tracer infusions were conducted to determine the rate of release of free fatty acid (Ra FFA) from peripheral tissue and the rate of secretion of VLDL-bound TGs by the liver.
resultsExogenous rhGH increased Ra FFA in children with large third-degree burns. Propranolol decreased Ra FFA, but the rate of secretion of fatty acids in the form of VLDL-TG from the liver was maintained. Plasma FFA, as opposed to fatty acids newly synthesized in the liver, were the primary precursors for hepatic triglyceride synthesis.
conclusionsThe administration of propranolol to burned children receiving rhGH is safe, has salutary cardiovascular effects, decreases the release of FFA from adipose tissue and increases the efficiency of the liver in secreting fatty acids as VLDL TGs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.