ArticleAnnals of surgery1996
Loss of upper respiratory tract immunity with parenteral feeding.
Article in Annals of surgery, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 3 of them syntheses that pooled it.
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Who cites it
44 citing papers in PubMed, 3 syntheses or guidelines pooled it, 188 citations in OpenAlex.
- Haemodynamic goal-directed therapy and postoperative infections: earlier is better. A systematic review and meta-analysis.Critical care (London, England) · 2011Pooled it
- Enteral versus parenteral nutrition after gastrointestinal surgery: a systematic review and meta-analysis of randomized controlled trials in the English literature.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2008Pooled it
- Meta-analysis of parenteral nutrition versus enteral nutrition in patients with acute pancreatitis.BMJ (Clinical research ed.) · 2004Pooled it
- A randomized trial of isonitrogenous enteral diets after severe trauma. An immune-enhancing diet reduces septic complications.Annals of surgery · 1996Trial
- Gastrointestinal axis in post-traumatic sepsis: from molecular mechanisms to translational perspectives.Frontiers in immunology · 2026Review
- Catabolic rewiring in cancer impacts dietary interventions.Communications biology · 2025Review
- Early prediction and prevention of infected pancreatic necrosis.World journal of gastroenterology · 2024Article
- Optimization of the target strategy of perioperative infusion therapy based on monitoring data of central hemodynamics in order to prevent complications.Frontiers in medicine · 2022Review
- Gastrointestinal immune and microbiome changes during parenteral nutrition.American journal of physiology. Gastrointestinal and liver physiology · 2017Review
- Bombesin Preserves Goblet Cell Resistin-Like Molecule β During Parenteral Nutrition but Not Other Goblet Cell Products.JPEN. Journal of parenteral and enteral nutrition · 2016Article
- Innate Mucosal Immune System Response of BALB/c vs C57BL/6 Mice to Injury in the Setting of Enteral and Parenteral Feeding.JPEN. Journal of parenteral and enteral nutrition · 2016Article
- The gastrointestinal immune system: Implications for the surgical patient.Current problems in surgery · 2016Review
- Parenteral nutrition decreases paneth cell function and intestinal bactericidal activity while increasing susceptibility to bacterial enteroinvasion.JPEN. Journal of parenteral and enteral nutrition · 2014Article
- The enteric nervous system neuropeptide, bombesin, reverses innate immune impairments during parenteral nutrition.Annals of surgery · 2014Article
- IL-25 improves luminal innate immunity and barrier function during parenteral nutrition.Annals of surgery · 2014Article
- Advantages of enteral nutrition over parenteral nutrition.Therapeutic advances in gastroenterology · 2013Article
- Enteral nutrition discontinuation and outcomes in general critically ill patients.Clinics (Sao Paulo, Brazil) · 2013Article
- [Immunonutrition after trauma].Der Unfallchirurg · 2011Article
- Nutrition and gut immunity.The Surgical clinics of North America · 2011Review
- Decreased phospho-Akt signaling in a mouse model of total parenteral nutrition: a potential mechanism for the development of intestinal mucosal atrophy.American journal of physiology. Gastrointestinal and liver physiology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe authors examine the effect of route and type of nutrition on an established upper respiratory tract immunity and investigate potential mechanisms for increased pneumonia rates in critically injured patients fed parenterally. SUMMARY BACKGROUND DATA: The primary immunologic defense against many mucosal infections is IgA. Prior work shows that mice fed total parenteral nutrition (TPN) solutions either intravenously or intragastrically had small intestinal gut-associated lymphoid tissue (GALT) atrophy along with decreased intestinal IgA compared with animals fed complex enteral diets. The small intestine is postulated to be the origin of most mucosal immunity, both intraintestinal and extraintestinal. The impact of diets affecting GALT, small intestine IgA, and upper respiratory tract immunity is studied.
methodsMale Institute of Cancer Research mice underwent intranasal inoculation with a mouse-specific influenza virus to establish immunity. Three weeks later, the mice were randomized to chow, intragastric Nutren (Clintec, Chicago, IL), intravenous TPN, or intragastric TPN. After 5 days of feeding, mice were challenged with intranasal virus and killed at 40 hours to determine viral shedding from the upper respiratory tract.
resultsDespite similar body weights, there was significant atrophy in the Peyer's patch cells from animals fed the TPN solution intravenously or intragastrically. There was no viral shedding in any animal fed via the gastrointestinal tract, whereas 5 of 10 animals fed intravenous TPN had continued viral shedding.
conclusionsThe IgA-dependent upper respiratory tract immunity was preserved with enteral feeding but not with intravenous feeding. Upper respiratory tract immunity is not dependent on intestinal GALT mass but is influenced by route of nutrition. The underlying mechanisms may explain the higher pneumonia rate in critically injured patients fed parenterally.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.