ArticleThe American journal of pathology1996
Platelet-derived growth factor-BB induces renal tubulointerstitial myofibroblast formation and tubulointerstitial fibrosis.
Article in The American journal of pathology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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Who cites it
46 citing papers in PubMed, 228 citations in OpenAlex.
- Mechanism study of circCCDC134 regulating the biological behaviors of PDGF-BB-induced oral mucosal fibroblast.Scientific reports · 2026Article
- Modulating Renal Fibrosis: The Emerging Role of Hepatocyte Growth Factor.International journal of nephrology · 2026Review
- Unveiling neuroimmunology profile of immunological non-responders in HIV: a multimodal MRI approach.Frontiers in immunology · 2024Article
- Cellular cross-talk drives mesenchymal transdifferentiation in diabetic kidney disease.Frontiers in medicine · 2024Review
- The uPA/uPAR System Orchestrates the Inflammatory Response, Vascular Homeostasis, and Immune System in Fibrosis Progression.International journal of molecular sciences · 2023Review
- Myofibroblast transcriptome indicates SFRP2Nature communications · 2021Article
- Renal fibrosis due to multiple cisplatin treatment is exacerbated by kinin B1 receptor antagonism.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2021Article
- Excessive activation of the TLR9/TGF-β1/PDGF-B pathway in the peripheral blood of patients with systemic lupus erythematosus.Arthritis research & therapy · 2017Article
- Progression of chronic kidney disease: too much cellular talk causes damage.Kidney international · 2017Review
- Drugs and Targets in Fibrosis.Frontiers in pharmacology · 2017Review
- Myofibroblasts and lung fibrosis induced by carbon nanotube exposure.Particle and fibre toxicology · 2016Review
- Megalin-Mediated Tubuloglomerular Alterations in High-Fat Diet-Induced Kidney Disease.Journal of the American Society of Nephrology : JASN · 2016Article
- Pathogenesis of Type 2 Epithelial to Mesenchymal Transition (EMT) in Renal and Hepatic Fibrosis.Journal of clinical medicine · 2015Review
- Pbx1-dependent control of VMC differentiation kinetics underlies gross renal vascular patterning.Development (Cambridge, England) · 2015Article
- Article
- Platelet-derived growth factors (PDGFs) in glomerular and tubulointerstitial fibrosis.Kidney international supplements · 2014Review
- The origin of scar-forming kidney myofibroblasts.Nature medicine · 2013Article
- Cytokine mediated tissue fibrosis.Biochimica et biophysica acta · 2013Review
- The inhibitory effect of chimeric decoy oligodeoxynucleotide against NF-κB and Sp1 in renal interstitial fibrosis.Journal of molecular medicine (Berlin, Germany) · 2013Article
- PDGFRβ expression in tumor stroma of pancreatic adenocarcinoma as a reliable prognostic marker.Medical oncology (Northwood, London, England) · 2012Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tubulointerstitial fibrosis correlates closely with renal function, although the mechanism regulating tubulointerstitial fibrogenesis remains poorly understood. Since platelet-derived growth factor (PDGF) is a growth factor for fibroblasts, we examined the effect of daily (for 7 days) PDGF-AA or PDGF-BB administration on renal tubulointerstitial architecture in rats. PDGF-AA administration at a dose of 5 mg/kg did not affect the renal tubulointerstitium. By comparison, PDGF-BB induced dose-dependent renal tubulointerstitial cell proliferation and fibrosis. At 5 mg/kg, PDGF-BB increased BrdU labeling in tubulointerstitial fibroblasts at 24 hours (19-fold), which peaked at 72 hours (23-fold) with bromodeoxyuridine uptake returning to control values by 7 days. Tubulointerstitial proliferation was associated with the differentiation of these cells into myofibroblasts as evidenced by alpha-smooth muscle actin expression beginning on day 3. The expression of alpha-smooth muscle actin peaked on day 5 and had markedly declined by day 21. In addition, apoptotic cells were identified within the tubulointerstitium on day 3 and progressively increased through day 7, suggesting that the disappearance of myofibroblasts may have occurred through apoptosis. These changes were accompanied by increased expression of alpha 1 (III) collagen mRNA and interstitial accumulation of type III collagen within the renal cortex. By morphometric analysis, an approximately twofold increase in collagen III immunolabeling within the interstitial compartment was evident at 24 hours and peaked on days 5 to 7 (approximately fourfold). These data suggest that PDGF-BB may be an important mediator of tubulointerstitial hyperplasia and fibrosis.
Indexed as
Identifiers
8644858PMC1861538W112957796What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.