ArticleThe American journal of pathology1996
Is the EWS/FLI-1 fusion transcript specific for Ewing sarcoma and peripheral primitive neuroectodermal tumor? A report of four cases showing this transcript in a wider range of tumor types.
Article in The American journal of pathology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 113 citations in OpenAlex.
- Primary Intracranial Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor Mimicking Meningioma: A Case Report and Literature Review.Frontiers in oncology · 2020Article
- Huge peripheral primitive neuroectodermal tumor of the small bowel mesentery at nonage: A case report and review of the literature.World journal of clinical cases · 2016Article
- Unusual Clinical Presentation of Gastrointestinal Clear Cell Sarcoma.Gastrointestinal tumors · 2015Article
- Ewing's sarcoma family of tumors of the maxillary sinus: a case report of multidisciplinary examination enabling prompt diagnosis.International journal of clinical and experimental pathology · 2015Article
- Is it Askin Tumour? A Question You Must Ask Even in Elderly.Journal of clinical and diagnostic research : JCDR · 2014Article
- The evaluation of CD99 immunoreactivity and EWS/FLI1 translocation by fluorescence in situ hybridization in central PNETs and Ewing's sarcoma family of tumors.Pathology oncology research : POR · 2011Article
- Guidelines for histopathological specimen examination and diagnostic reporting of primary bone tumours.Clinical sarcoma research · 2011Article
- Pathobiologic markers of the ewing sarcoma family of tumors: state of the art and prediction of behaviour.Sarcoma · 2011Article
- Soft tissue tumors associated with EWSR1 translocation.Virchows Archiv : an international journal of pathology · 2010Review
- Perigastric extraskeletal Ewing's sarcoma: a case report.World journal of gastroenterology · 2009Article
- Analysis of CHOP rearrangement in pleomorphic liposarcomas using fluorescence in situ hybridization.Cancer science · 2009Article
- Ewing family of tumours involving the vulva and vagina: report of a series of four cases.Journal of clinical pathology · 2007Review
- Ewing's sarcoma: diagnostic, prognostic, and therapeutic implications of molecular abnormalities.Journal of clinical pathology · 2003Review
- Biology of EWS/ETS fusions in Ewing's family tumors.Oncogene · 2001Review
- Diagnosis and classification of small round-cell tumors of childhood.The American journal of pathology · 1999Article
- Application of comparative genomic hybridization, spectral karyotyping, and microarray analysis in the identification of subtype-specific patterns of genomic changes in rhabdomyosarcoma.Neoplasia (New York, N.Y.) · 1999Article
- Use of tumor-specific gene expression for the differential diagnosis of neuroblastoma from other pediatric small round-cell malignancies.The American journal of pathology · 1999Article
- Diagnosis and classification of the small round-cell tumors of childhood.The American journal of pathology · 1999Review
- Progress in the molecular biology of ewing tumors.Sarcoma · 1998Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The presence of t(11;22)(q24;q12) is often considered diagnostic of Ewing sarcoma and peripheral primitive neuroectodermal tumor. We report four cases, all of which possessed this translocation as detected by reverse transcriptase polymerase chain reaction and confirmed by sequencing with or without fluorescent in situ hybridization, but none of which were Ewing sarcoma or peripheral primitive neuroectodermal tumor by histological criteria. Two were polyphenotypic tumors and two were mixed embryonal and alveolar rhabdomyosarcomas. Only one case was positive for MIC2 by immunohistochemistry and only in a rare cell. Two cases (one polyphenotypic tumor and one rhabdomyosarcoma) had double minute chromosomes with > 100 copies of the MDM2 gene. The presence of the t(11;22)(q24;ql2) translocation should probably not be considered diagnostic of Ewing sarcoma and peripheral primitive neuroectodermal tumor in the absence of supporting histological evidence. The presence of this translocation in Ewing sarcoma and peripheral primitive neuroectodermal tumor has been taken as evidence that these two tumors are related. Extending this relationship to include some polyphenotypic tumors and some rhabdomyosarcomas may not be justified unless additional evidence is gathered. Pathologists and oncologists will need to decide whether treatment regimens for tumors are better based on phenotype rather than genotype when these two profiles are seemingly in conflict.
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8644855PMC1861517W2176099398What OpenQuestion holds
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