ArticleAmerican journal of human genetics1996
Nonparametric simulation-based statistics for detecting linkage in general pedigrees.
Article in American journal of human genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Rare and common variant discovery in complex disease: the IBD case study.Human molecular genetics · 2019Review
- Genome-wide linkage scan to identify loci associated with type 2 diabetes and blood lipid phenotypes in the Sikh Diabetes Study.PloS one · 2011Article
- Linkage analysis in the next-generation sequencing era.Human heredity · 2011Review
- Exact trait-model-free tests for linkage detection in pedigrees.Annals of human genetics · 2008Article
- Identity-by-descent estimation and mapping of qualitative traits in large, complex pedigrees.Genetics · 2008Article
- Analysis of families with common variable immunodeficiency (CVID) and IgA deficiency suggests linkage of CVID to chromosome 16q.Human genetics · 2006Article
- Sex-specific genetic architecture of whole blood serotonin levels.American journal of human genetics · 2005Article
- A genome-wide scan for primary open-angle glaucoma (POAG): the Barbados Family Study of Open-Angle Glaucoma.Human genetics · 2003Article
- Genome scan for loci involved in cleft lip with or without cleft palate, in Chinese multiplex families.American journal of human genetics · 2002Article
- Mapping susceptibility genes for bipolar disorder: a pharmacogenetic approach based on excellent response to lithium.Molecular psychiatry · 2001Article
- Further evidence for a bipolar risk gene on chromosome 12q24 suggested by investigation of haplotype sharing and allelic association in patients from the Faroe Islands.Molecular psychiatry · 2001Article
- Association and linkage studies of candidate genes involved in GABAergic neurotransmission in lithium-responsive bipolar disorder.Journal of psychiatry & neuroscience : JPN · 2000Article
- Power comparison of parametric and nonparametric linkage tests in small pedigrees.American journal of human genetics · 2000Article
- Localisation of a gene for prepubertal periodontitis to chromosome 11q14 and identification of a cathepsin C gene mutation.Journal of medical genetics · 2000Article
- Chromosome 6p influences on different dyslexia-related cognitive processes: further confirmation.American journal of human genetics · 2000Article
- On a randomization procedure in linkage analysis.American journal of human genetics · 1999Article
- Linkage of type 2 diabetes mellitus and of age at onset to a genetic location on chromosome 10q in Mexican Americans.American journal of human genetics · 1999Article
- Absence of linkage of phonological coding dyslexia to chromosome 6p23-p21.3 in a large family data set.American journal of human genetics · 1998Article
- Evidence for oligogenic inheritance of type 1 diabetes in a large Bedouin Arab family.The Journal of clinical investigation · 1998Article
- Association of the FcepsilonRIbeta gene with bronchial hyper-responsiveness in an Italian population.Journal of medical genetics · 1998Article
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Authors and funding
4 authors.
Funding
Abstract
We present here four nonparametric statistics for linkage analysis that test whether pairs of affected relatives share marker alleles more often than expected. These statistics are based on simulating the null distribution of a given statistic conditional on the unaffecteds' marker genotypes. Each statistic uses a different measure of marker sharing: the SimAPM statistic uses the simulation-based affected-pedigree-member measure based on identity-by-state (IBS) sharing. The SimKIN (kinship) measure is 1.0 for identity-by-descent (IBD) sharing, 0.0 for no IBD status sharing, and the kinship coefficient when the IBD status is ambiguous. The simulation-based IBD (SimIBD) statistic uses a recursive algorithm to determine the probability of two affecteds sharing a specific allele IBD. The SimISO statistic is identical to SimIBD, except that it also measures marker similarity between unaffected pairs. We evaluated our statistics on data simulated under different two-locus disease models, comparing our results to those obtained with several other nonparametric statistics. Use of IBD information produces dramatic increases in power over the SimAPM method, which uses only IBS information. The power of our best statistic in most cases meets or exceeds the power of the other nonparametric statistics. Furthermore, our statistics perform comparisons between all affected relative pairs within general pedigrees and are not restricted to sib pairs or nuclear families.
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8644751PMC1914666What OpenQuestion holds
Registered trials
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