ArticleAmerican journal of human genetics1996
Rapid detection of regionally clustered germ-line BRCA1 mutations by multiplex heteroduplex analysis. UKCCCR Familial Ovarian Cancer Study Group.
Article in American journal of human genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 78 citations in OpenAlex.
- BRCA1 gene: function and deficiency.International journal of clinical oncology · 2018Review
- Detection of false positive mutations in BRCA gene by next generation sequencing.Familial cancer · 2017Article
- Genomic Biomarkers for Breast Cancer Risk.Advances in experimental medicine and biology · 2016Review
- Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2015Article
- MDC1 and RNF8 function in a pathway that directs BRCA1-dependent localization of PALB2 required for homologous recombination.Journal of cell science · 2012Article
- High proportion of recurrent germline mutations in the BRCA1 gene in breast and ovarian cancer patients from the Prague area.Breast cancer research : BCR · 2005Article
- BRCA1 and BRCA2 mutations in Scotland and Northern Ireland.British journal of cancer · 2003Article
- Novel mutations in the BRCA1 and BRCA2 genes in Iranian women with early-onset breast cancer.Breast cancer research : BCR · 2002Article
- Combined SSCP/duplex analysis by capillary electrophoresis for more efficient mutation detection.Nucleic acids research · 2001Article
- Double primary cancers of the breast and thyroid in women: molecular analysis and genetic implications.Familial cancer · 2001Article
- Rapid detection of deletion, insertion, and substitution mutations via heteroduplex analysis using capillary- and microchip-based electrophoresis.Genome research · 2000Article
- Functional assay for BRCA1: mutagenesis of the COOH-terminal region reveals critical residues for transcription activation.Cancer research · 2000Article
- Amplification of PCR products in excess of 600 base pairs using DNA extracted from decalcified, paraffin wax embedded bone marrow trephine biopsies.Molecular pathology : MP · 2000Article
- The genetic epidemiology of early-onset epithelial ovarian cancer: a population-based study.American journal of human genetics · 1999Article
- The genetics of inherited breast cancer.Journal of mammary gland biology and neoplasia · 1998Review
- Frequency and carrier risk associated with common BRCA1 and BRCA2 mutations in Ashkenazi Jewish breast cancer patients.American journal of human genetics · 1998Article
- Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium.American journal of human genetics · 1998Article
- Human BRCA1 inhibits growth in yeast: potential use in diagnostic testing.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Frequently occurring germ-line mutations of the BRCA1 gene in ovarian cancer families from Russia.American journal of human genetics · 1997Article
- Analysis of BRCA1 and BRCA2 mutations in Hungarian families with breast or breast-ovarian cancer.American journal of human genetics · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Germ-line mutations of the BRCA1 gene are responsible for a substantial proportion of families with multiple cases of early-onset breast and/or ovarian cancer. Since the isolation of BRCA1 last year, >65 distinct mutations scattered throughout the coding region have been detected, making analysis of the gene time consuming and technically challenging. We have developed a multiplex heteroduplex analysis that is designed to analyze one-quarter of the coding sequence in a single-step screening procedure and that will detect approximately 50% of all BRCA1 mutations so far reported in breast/ovarian cancer families. We have used this technique to analyze BRCA1 in 162 families with a history of breast and/or ovarian cancer and identified 12 distinct mutations in 35 families.
Indexed as
Identifiers
8644703PMC1914578W90103378What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.