ArticleProceedings of the National Academy of Sciences of the United States of America1996
E2F1 and E1A(12S) have a homologous activation domain regulated by RB and CBP.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 104 citations in OpenAlex.
- Article
- Downregulating CREBBP inhibits proliferation and cell cycle progression and induces daunorubicin resistance in leukemia cells.Molecular medicine reports · 2020Article
- Exploitation of EP300 and CREBBP Lysine Acetyltransferases by Cancer.Cold Spring Harbor perspectives in medicine · 2017Review
- Two independent regions of simian virus 40 T antigen increase CBP/p300 levels, alter patterns of cellular histone acetylation, and immortalize primary cells.Journal of virology · 2013Article
- An IKKα-E2F1-BMI1 cascade activated by infiltrating B cells controls prostate regeneration and tumor recurrence.Genes & development · 2013Article
- LXCXE-independent chromatin remodeling by Rb/E2f mediates neuronal quiescence.Cell cycle (Georgetown, Tex.) · 2013Article
- Involvement of p300/CBP and epigenetic histone acetylation in TGF-β1-mediated gene transcription in mesangial cells.American journal of physiology. Renal physiology · 2013Article
- JAZ mediates G1 cell cycle arrest by interacting with and inhibiting E2F1.Cell cycle (Georgetown, Tex.) · 2011Article
- Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy.Molecular cell · 2009Article
- Structure of the retinoblastoma protein bound to adenovirus E1A reveals the molecular basis for viral oncoprotein inactivation of a tumor suppressor.Genes & development · 2007Article
- Drosophila dCBP is involved in establishing the DNA replication checkpoint.Molecular and cellular biology · 2007Article
- MAGE-A1 interacts with adaptor SKIP and the deacetylase HDAC1 to repress transcription.Nucleic acids research · 2004Article
- Identification of E-box factor TFE3 as a functional partner for the E2F3 transcription factor.Molecular and cellular biology · 2003Article
- The adenovirus E1A oncoprotein recruits the cellular TRRAP/GCN5 histone acetyltransferase complex.Oncogene · 2003Article
- Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor.Genes & development · 2002Article
- A key role of the hSNF5/INI1 tumour suppressor in the control of the G1-S transition of the cell cycle.Oncogene · 2002Article
- Gene expression changes in response to E2F1 activation.Nucleic acids research · 2002Article
- Inhibition of crystallin expression and induction of apoptosis by lens-specific E1A expression in transgenic mice.Oncogene · 2002Article
- Review
- Role of LXCXE motif-dependent interactions in the activity of the retinoblastoma protein.Oncogene · 2001Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The E2F1 transcription factor has a well-characterized activation domain at its C terminus and the E1A protein has a recently defined activation domain at its N terminus. Here we show that these activation domains are highly related in sequence. The sequence homology reflects, at least partly, the conservation of common binding sites for the RB and CBP/p300 proteins, which are preserved in the same relative order along E2F1 and E1A. Furthermore, the interaction of RB and CBP with these two activation domains results in the same functional consequences: RB represses both activation domains, whereas CBP stimulates them. We conclude that the activation domains of E1A(12s) and E2F1 belong to a novel functional class, characterized by specific protein binding sites. The implication of this conservation with respect to E1A-induced stimulation of E2F activity is discussed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.