ArticleProceedings of the National Academy of Sciences of the United States of America1996
Conservation of synteny between the genome of the pufferfish (Fugu rubripes) and the region on human chromosome 14 (14q24.3) associated with familial Alzheimer disease (AD3 locus)
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 70 citations in OpenAlex.
- Modulation of adrenocorticotrophin hormone (ACTH)-induced expression of stress-related genes by PUFA in inter-renal cells from European sea bass (Dicentrarchus labrax).Journal of nutritional science · 2015Article
- Identification, cloning and characterization of a plasma membrane zinc efflux transporter, TrZnT-1, from fugu pufferfish (Takifugu rubripes).The Biochemical journal · 2006Article
- AP1 genes in Fugu indicate a divergent transcriptional control to that of mammals.Mammalian genome : official journal of the International Mammalian Genome Society · 2003Article
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- Transcription factor ATF3 partially transforms chick embryo fibroblasts by promoting growth factor-independent proliferation.Oncogene · 2001Article
- Cytogenetic and molecular analysis of the pufferfish Tetraodon fluviatilis (Osteichthyes).Genetica · 2001Article
- Genomic sequence analysis of Fugu rubripes CFTR and flanking genes in a 60 kb region conserving synteny with 800 kb of human chromosome 7.Genome research · 2000Article
- Estimation of synteny conservation and genome compaction between pufferfish (Fugu) and human.Yeast (Chichester, England) · 2000Article
- Molecular cloning and characterization of the Fugu rubripes MEST/COPG2 imprinting cluster and chromosomal localization in Fugu and Tetraodon nigroviridis.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2000Article
- Generation and analysis of 25 Mb of genomic DNA from the pufferfish Fugu rubripes by sequence scanning.Genome research · 1999Article
- Genomic structure and comparative analysis of nine Fugu genes: conservation of synteny with human chromosome Xp22.2-p22.1.Genome research · 1999Article
- Analysis of 148 kb of genomic DNA around the wnt1 locus of Fugu rubripes.Genome research · 1999Article
- Classical and molecular cytogenetics of the pufferfish Tetraodon nigroviridis.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 1999Article
- Complete sequencing of the Fugu WAGR region from WT1 to PAX6: dramatic compaction and conservation of synteny with human chromosome 11p13.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Transgenic rats reveal functional conservation of regulatory controls between the Fugu isotocin and rat oxytocin genes.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Pufferfish and new paradigm for comparative genome analysis.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
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14 authors at 1 institution in 1 country.
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Abstract
The genome of the pufferfish (Fugu rubripes) (400 Mb) is approximately 7.5 times smaller than the human genome, but it has a similar gene repertoire to that of man. If regions of the two genomes exhibited conservation of gene order (i.e., were syntenic), it should be possible to reduce dramatically the effort required for identification of candidate genes in human disease loci by sequencing syntenic regions of the compact Fugu genome. We have demonstrated that three genes (dihydrolipoamide succinyltransferase, S31iii125, and S20i15), which are linked to FOS in the familial Alzheimer disease focus (AD3) on human chromosome 14, have homologues in the Fugu genome adjacent to Fugu cFOS. The relative gene order of cFOS, S31iii125, and S20i15 was the same in both genomes, but in Fugu these three genes lay within a 12.4-kb region, compared to >600 kb in the human AD3 locus. These results demonstrate the conservation of synteny between the genomes of Fugu and man and highlight the utility of this approach for sequence-based identification of genes in human disease loci.
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