ArticleProceedings of the National Academy of Sciences of the United States of America1996
Conserved motifs in prokaryotic and eukaryotic polypeptide release factors: tRNA-protein mimicry hypothesis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 136 citations in OpenAlex.
- Translation in Mitochondrial Ribosomes.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Intramolecular chaperone-mediated secretion of an Rhs effector toxin by a type VI secretion system.Nature communications · 2020Article
- R213I mutation in release factor 2 (RF2) is one step forward for engineering an omnipotent release factor in bacteriaThe Journal of biological chemistry · 2017Article
- Origins and Early Evolution of the tRNA Molecule.Life (Basel, Switzerland) · 2015Review
- A genetic approach for analyzing the co-operative function of the tRNA mimicry complex, eRF1/eRF3, in translation termination on the ribosome.Nucleic acids research · 2014Article
- RF3:GTP promotes rapid dissociation of the class 1 termination factor.RNA (New York, N.Y.) · 2014Article
- Article
- Ribosome evolution: emergence of peptide synthesis machinery.Journal of biosciences · 2011Review
- Article
- Structural aspects of translation termination on the ribosome.RNA (New York, N.Y.) · 2011Review
- Identification of a cellular factor that modulates HIV-1 programmed ribosomal frameshifting.The Journal of biological chemistry · 2010Article
- Cosuppression of eukaryotic release factor 1-1 in Arabidopsis affects cell elongation and radial cell division.Plant physiology · 2005Article
- Decoding the decoding region: analysis of eukaryotic release factor (eRF1) stop codon-binding residues.Journal of molecular evolution · 2005Article
- Assessing functional divergence in EF-1alpha and its paralogs in eukaryotes and archaebacteria.Nucleic acids research · 2003Article
- Stop codon selection in eukaryotic translation termination: comparison of the discriminating potential between human and ciliate eRF1s.The EMBO journal · 2003Article
- Viable nonsense mutants for the essential gene SUP45 of Saccharomyces cerevisiae.BMC molecular biology · 2003Article
- A peptide chain release factor 2 affects the stability of UGA-containing transcripts in Arabidopsis chloroplasts.The Plant cell · 2002Article
- Evolutionary conservation of reactions in translation.Microbiology and molecular biology reviews : MMBR · 2002Review
- Polypeptide release at sense and noncognate stop codons by localized charge-exchange alterations in translational release factors.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- HemK, a class of protein methyl transferase with similarity to DNA methyl transferases, methylates polypeptide chain release factors, and hemK knockout induces defects in translational termination.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Translation termination requires two codon-specific polypeptide release factors in prokaryotes and one omnipotent factor in eukaryotes. Sequences of 17 different polypeptide release factors from prokaryotes and eukaryotes were compared. The prokaryotic release factors share residues split into seven motifs. Conservation of many discrete, perhaps critical, amino acids is observed in eukaryotic release factors, as well as in the C-terminal portion of elongation factor (EF) G. Given that the C-terminal domains of EF-G interacts with ribosomes by mimicry of a tRNA structure, the pattern of conservation of residues in release factors may reflect requirements for a tRNA-mimicry for binding to the A site of the ribosome. This mimicry would explain why release factors recognize stop codons and suggests that all prokaryotic and eukaryotic release factors evolved from the progenitor of EF-G.
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