ArticleProceedings of the National Academy of Sciences of the United States of America1996
Expression of a renal type I sodium/phosphate transporter (NaPi-1) induces a conductance in Xenopus oocytes permeable for organic and inorganic anions.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 142 citations in OpenAlex.
- How the diagnosis and the management of genetic renal phosphate leak impact the life of kidney stone formers?Urolithiasis · 2022Article
- Promising Epigenetic Biomarkers Associated With Cancer-Associated-Fibroblasts for Progression of Kidney Renal Clear Cell Carcinoma.Frontiers in genetics · 2021Article
- The mechanism and regulation of vesicular glutamate transport: Coordination with the synaptic vesicle cycle.Biochimica et biophysica acta. Biomembranes · 2020Review
- Tissue-Wide Gene Expression Analysis of Sodium/Phosphate Co-Transporters in Pigs.International journal of molecular sciences · 2019Article
- Roles of Phosphate in Skeleton.Frontiers in endocrinology · 2019Review
- Phosphate transport: from microperfusion to molecular cloning.Pflugers Archiv : European journal of physiology · 2019Article
- Probable Potential Role of Urate Transporter Genes in the Development of Metabolic Disorders.Cureus · 2018Review
- Article
- Vesicular glutamate transporters as anion channels?Pflugers Archiv : European journal of physiology · 2016Review
- Genetic variants of SLC17A1 are associated with cholesterol homeostasis and hyperhomocysteinaemia in Japanese men.Scientific reports · 2015Article
- The Concise Guide to PHARMACOLOGY 2013/14: transporters.British journal of pharmacology · 2013Article
- The renal urate transporter SLC17A1 locus: confirmation of association with gout.Arthritis research & therapy · 2012Article
- Successful prediction of substrate-binding pocket in SLC17 transporter sialin.The Journal of biological chemistry · 2012Article
- Vesicular and plasma membrane transporters for neurotransmitters.Cold Spring Harbor perspectives in biology · 2012Review
- Neurotransmitter corelease: mechanism and physiological role.Annual review of physiology · 2012Review
- Sirolimus induced phosphaturia is not caused by inhibition of renal apical sodium phosphate cotransporters.PloS one · 2012Article
- The emergence of phosphate as a specific signaling molecule in bone and other cell types in mammals.Cellular and molecular life sciences : CMLS · 2011Review
- Hereditary disorders of renal phosphate wasting.Nature reviews. Nephrology · 2010Review
- Type 1 sodium-dependent phosphate transporter (SLC17A1 Protein) is a Cl(-)-dependent urate exporter.The Journal of biological chemistry · 2010Article
- Vesicular glutamate transport promotes dopamine storage and glutamate corelease in vivo.Neuron · 2010Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two distinct molecular types (I and II) of renal proximal tubular brush border Na+/Pi cotransporters have been identified by expression cloning on the basis of their capacity to induce Na+-dependent Pi influx in tracer experiments. Whereas the type II transporters (e.g., NaPi-2 and NaPi-3) resemble well known characteristics of brush border Na+/Pi cotransport, little is known about the properties of the type I transporter (NaPi-1). In contrast to type II, type I transporters produced electrogenic transport only at high extracellular Pi concentrations (> or =3 mM). On the other hand, expression of NaPi-1 induced a Cl- conductance in Xenopus laevis oocytes, which was inhibited by Cl- channel blockers [5-nitro-2-(3-phenylpropylamino)benzoic acid (NPPB) > niflumic acid >> 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid]. Further, the Cl- conductance was inhibited by the organic anions phenol red, benzylpenicillin (penicillin G), and probenecid. These organic anions induced outwardly directed currents in the absence of Cl-. In tracer studies, we observed uptake of benzylpenicillin with a Km of 0.22 mM; benzylpenicillin uptake was inhibited by NPPB and niflumic acid. These findings suggest that the type I Na+/Pi cotransporter functions also as a novel type of anion channel permeable not only for Cl- but also for organic anions. Such an apical anion channel could serve an important role in the transport of Cl- and the excretion of anionic xenobiotics.
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