Evidence map›Paper›PMID 8643549›Full record

ReviewProceedings of the National Academy of Sciences of the United States of America1996

The viruses in all of us: characteristics and biological significance of human endogenous retrovirus sequences.

R Löwer, J Löwer, R Kurth

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 217 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
217citing papers in PubMed, 2 pooled it
56.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

217 citing papers in PubMed, 2 syntheses or guidelines pooled it, 686 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Genes & diseases · 2026
    Article
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  8. The role of HERV envelope protein in ovarian cancer.Frontiers in cell and developmental biology · 2025
    Review
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157 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

R LöwerPaul-Ehrlich-Institut, Langen, Germany.
J Löwer
R Kurth
Paul Ehrlich Institut · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human endogenous retroviruses (HERVs) are very likely footprints of ancient germ-cell infections. HERV sequences encompass about 1% of the human genome. HERVs have retained the potential of other retroelements to retrotranspose and thus to change genomic structure and function. The genomes of almost all HERV families are highly defective. Recent progress has allowed the identification of the biologically most active family, HTDV/HERV-K, which codes for viral proteins and particles and is highly expressed in germ-cell tumors. The demonstrable and potential roles of HTDV/HERV-K as well as of other human elements in disease and in maintaining genome plasticity are illustrated.

Indexed as

Genome, HumanAntibody FormationFemaleHIV SeropositivityHumansMaleNeoplasmsRetroelementsRetroviridaeRNA-Directed DNA PolymeraseRetroelementsRNA-Directed DNA Polymerase

Identifiers

PMID8643549
PMCPMC39218
OpenAlexW2154121432

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.