ArticleProceedings of the National Academy of Sciences of the United States of America1996
Exchanges are not equally able to enhance meiotic chromosome segregation in yeast.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed.
- Separable downmodulation of meiotic axis protein deposition and DNA break induction at chromosome ends.eLife · 2026Article
- Meiosis in budding yeast.Genetics · 2023Article
- Article
- Female Meiosis: Synapsis, Recombination, and Segregation inGenetics · 2018Review
- Article
- Meiotic Centromere Coupling and Pairing Function by Two Separate Mechanisms in Saccharomyces cerevisiae.Genetics · 2017Article
- Insights into epigenetic landscape of recombination-free regions.Chromosoma · 2016Review
- Meiotic Recombination: The Essence of Heredity.Cold Spring Harbor perspectives in biology · 2015Review
- Examining variation in recombination levels in the human female: a test of the production-line hypothesis.American journal of human genetics · 2014Article
- Global linkage map connects meiotic centromere function to chromosome size in budding yeast.G3 (Bethesda, Md.) · 2013Article
- High throughput sequencing reveals alterations in the recombination signatures with diminishing Spo11 activity.PLoS genetics · 2013Article
- Article
- Altered patterns of multiple recombinant events are associated with nondisjunction of chromosome 21.Human genetics · 2012Article
- Human aneuploidy: mechanisms and new insights into an age-old problem.Nature reviews. Genetics · 2012Review
- Article
- Etiology of Down syndrome: Evidence for consistent association among altered meiotic recombination, nondisjunction, and maternal age across populations.American journal of medical genetics. Part A · 2009Article
- Article
- Rec25 and Rec27, novel linear-element components, link cohesin to meiotic DNA breakage and recombination.Current biology : CB · 2008Article
- New insights into human nondisjunction of chromosome 21 in oocytes.PLoS genetics · 2008Article
- Targeted induction of meiotic double-strand breaks reveals chromosomal domain-dependent regulation of Spo11 and interactions among potential sites of meiotic recombination.Nucleic acids research · 2008Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Homologous chromosomes pair, and then migrate to opposite poles of the spindle at meiosis I. In most eukaryotic organisms, reciprocal recombinations (crossovers) between the homologs are critical to the success of this process. Individuals with defects in meiotic recombination typically produce high levels of aneuploid gametes and exhibit low fertility or are sterile. The experiments described here were designed to test whether different crossovers are equally able to contribute to the fidelity of meiotic chromosome segregation in yeast. These experiments were performed with model chromosomes with which it was possible to control and measure the distributions of meiotic crossovers in wild-type cells. Physical and genetic approaches were used to map crossover positions on model chromosomes and to correlate crossover position with meiotic segregation behavior. The results show that crossovers at different chromosomal positions have different abilities to enhance the fidelity of meiotic segregation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.