ArticleProceedings of the National Academy of Sciences of the United States of America1996
Expression of transduced genes in mice generated by infecting blastocysts with avian leukosis virus-based retroviral vectors.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 39 citations in OpenAlex.
- Strategies for Targeting Retroviral Integration for Safer Gene Therapy: Advances and Challenges.Frontiers in molecular biosciences · 2021Review
- Development of genetically flexible mouse models of sarcoma using RCAS-TVA mediated gene delivery.PloS one · 2014Article
- Production of avian retroviruses and tissue-specific somatic retroviral gene transfer in vivo using the RCAS/TVA system.Nature protocols · 2012Article
- The core element of a CpG island protects avian sarcoma and leukosis virus-derived vectors from transcriptional silencing.Journal of virology · 2008Article
- Gene targeting to the stroma of the prostate and bone.Differentiation; research in biological diversity · 2008Review
- Use of avian retroviral vectors to introduce transcriptional regulators into mammalian cells for analyses of tumor maintenance.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Induction of ovarian cancer by defined multiple genetic changes in a mouse model system.Cancer cell · 2002Article
- Development of an avian leukosis-sarcoma virus subgroup A pseudotyped lentiviral vector.Journal of virology · 2001Article
- Restricting expression prolongs expression of foreign genes introduced into animals by retroviruses.Journal of virology · 2000Article
- Neural crest-directed gene transfer demonstrates Wnt1 role in melanocyte expansion and differentiation during mouse development.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Development of a flexible and specific gene delivery system for production of murine tumor models.Oncogene · 1999Review
- An avian sarcoma/leukosis virus-based gene trap vector for mammalian cells.Journal of virology · 1999Article
- Expression of a murine leukemia virus Gag-Escherichia coli RNase HI fusion polyprotein significantly inhibits virus spread.Journal of virology · 1997Article
- A Versatile Gene Delivery System for Efficient and Tumor Specific Gene ManipulationDiscoveries (Craiova, Romania)Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transgenic mouse lines have been developed that express the tv-a receptor under the control of the chicken beta-actin promoter. These mice express the tv-a receptor in most or all tissues and in the early embryo. An avian leukosis virus (ALV)-based retroviral vector system was used for the efficient delivery of genes into preimplantation mouse embryos from these transgenic lines. Experimental animals could be generated quickly and easily by infecting susceptible blastocysts with ALV-based retroviral vectors. Expression of the delivered genes was controlled by either the constitutive viral promoter contained in the long terminal repeat or an internal nonviral tissue-specific promoter. Mating the infected founder chimeric animals produced animals that carry the ALV provirus as a transgene. A subset of the integrated proviruses expressed the chloramphenicol acetyltransferase reporter gene from either the promoter in the long terminal repeat or an internal promoter, which we believe indicates that many of the sites that are accessible to viral DNA insertion in preimplantation embryos are incompatible with expression in older animals. This approach should prove useful for studies on murine cell lineage and development, providing models for studying oncogenesis, and testing gene therapy strategies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.