ArticleProceedings of the National Academy of Sciences of the United States of America1996
Activated Ras signals differentiation and expansion of CD4+8+ thymocytes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- A Focused Review of Ras Guanine Nucleotide-Releasing Protein 1 in Immune Cells and Cancer.International journal of molecular sciences · 2023Review
- Kras-Deficient T Cells Attenuate Graft-versus-Host Disease but Retain Graft-versus-Leukemia Activity.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
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- Deconstructing Ras signaling in the thymus.Molecular and cellular biology · 2012Article
- Role for Ets-2(Thr-72) transcription factor in stage-specific thymocyte development and survival.The Journal of biological chemistry · 2012Article
- Interaction of Ras with p110γ is required for thymic β-selection in the mouse.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Targeted Sos1 deletion reveals its critical role in early T-cell development.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Role of Ras/Raf/MEK/ERK signaling in physiological hematopoiesis and leukemia development.Immunologic research · 2011Review
- Regulation and Function of the RasGRP Family of Ras Activators in Blood Cells.Genes & cancer · 2011Article
- Oncogenic Kras initiates leukemia in hematopoietic stem cells.PLoS biology · 2009Article
- Selective regulation of TCR signaling pathways by the CD45 protein tyrosine phosphatase during thymocyte development.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- p21 Ras/impedes mitogenic signal propagation regulates cytokine production and migration in CD4 T cells.The Journal of biological chemistry · 2008Article
- Lck SH3 domain function is required for T-cell receptor signals regulating thymocyte development.Molecular and cellular biology · 2006Article
- Microarray analysis distinguishes differential gene expression patterns from large and small colony Thymidine kinase mutants of L5178Y mouse lymphoma cells.BMC bioinformatics · 2006Article
- Differential synergy of Notch and T cell receptor signaling determines alphabeta versus gammadelta lineage fate.The Journal of experimental medicine · 2006Article
- Deregulated expression of RasGRP1 initiates thymic lymphomagenesis independently of T-cell receptors.Oncogene · 2005Article
- The Vav family: at the crossroads of signaling pathways.Immunologic research · 2005Review
- Vav1/2/3-null mice define an essential role for Vav family proteins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells.The Journal of experimental medicine · 2003Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We describe a novel approach to assay the ability of particular gene products to signal transitions in lymphocyte differentiation in vivo. The method involves transfection of test expression constructs into RAG-1-deficient embryonic stem cells, which are subsequently assayed by the RAG-2-deficient blastocyst complementation approach. We have used this method to demonstrate that expression of activated Ras in CD4-8- (double negative, DN) prothymocytes in vivo induces their differentiation into small CD4+8+ (double positive, DP) cortical thymocytes with accompanying expansion to normal thymocyte numbers. However, activated Ras expression in DP cells does not cause proliferation or maturation to CD4+8- or CD4-8+ (single positive) thymocytes. Therefore, signaling through Ras is sufficient for promoting differentiation of DN to DP cells, but further differentiation requires the activity of additional signaling pathways.
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