ArticleProceedings of the National Academy of Sciences of the United States of America1996
Signal transduction in the archaeon Halobacterium salinarium is processed through three subfamilies of 13 soluble and membrane-bound transducer proteins.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 68 citations in OpenAlex.
- Structure of the archaeal chemotaxis protein CheY in a domain-swapped dimeric conformation.Acta crystallographica. Section F, Structural biology communications · 2019Article
- Cloning, refolding, purification and preliminary crystallographic analysis of the sensory domain of the Campylobacter chemoreceptor for multiple ligands (CcmL).Acta crystallographica. Section F, Structural biology communications · 2015Article
- Characterisation of a multi-ligand binding chemoreceptor CcmL (Tlp3) of Campylobacter jejuni.PLoS pathogens · 2014Article
- Chemotaxis in Campylobacter jejuni.European journal of microbiology & immunology · 2012Review
- Bacterial energy taxis: a global strategy?Archives of microbiology · 2010Review
- Posttranslational protein modification in Archaea.Microbiology and molecular biology reviews : MMBR · 2005Review
- A novel mode of sensory transduction in archaea: binding protein-mediated chemotaxis towards osmoprotectants and amino acids.The EMBO journal · 2002Article
- Probing the proton channel and the retinal binding site of Natronobacterium pharaonis sensory rhodopsin II.Biophysical journal · 2002Article
- Genomic perspective on the photobiology of Halobacterium species NRC-1, a phototrophic, phototactic, and UV-tolerant haloarchaeon.Photosynthesis research · 2001Article
- Genome sequence of Halobacterium species NRC-1.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Identification of methylation sites and effects of phototaxis stimuli on transducer methylation in Halobacterium salinarum.Journal of bacteriology · 1999Article
- Bioenergetics of the Archaea.Microbiology and molecular biology reviews : MMBR · 1999Review
- PAS domains: internal sensors of oxygen, redox potential, and light.Microbiology and molecular biology reviews : MMBR · 1999Review
- Enhanced function conferred on low-abundance chemoreceptor Trg by a methyltransferase-docking site.Journal of bacteriology · 1999Article
- Car: a cytoplasmic sensor responsible for arginine chemotaxis in the archaeon Halobacterium salinarum.The EMBO journal · 1999Article
- The specificity of interaction of archaeal transducers with their cognate sensory rhodopsins is determined by their transmembrane helices.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Comparison in vitro of a high- and a low-abundance chemoreceptor of Escherichia coli: similar kinase activation but different methyl-accepting activities.Journal of bacteriology · 1998Article
- Molecular characterization of Treponema pallidum mcp2, a putative chemotaxis protein gene.Infection and immunity · 1998Article
- An archaeal aerotaxis transducer combines subunit I core structures of eukaryotic cytochrome c oxidase and eubacterial methyl-accepting chemotaxis proteins.Journal of bacteriology · 1998Article
- Computational learning reveals coiled coil-like motifs in histidine kinase linker domains.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eubacterial transducers are transmembrane, methyl-accepting proteins central to chemotaxis systems and share common structural features. We identified a large family of transducer proteins in the Archaeon Halobacterium salinarium using a site-specific multiple antigenic peptide antibody raised against 23 amino acids, representing the highest homology region of eubacterial transducers. This immunological observation was confirmed by isolating 13 methyl-accepting taxis genes using a 27-mer oligonucleotide probe, corresponding to conserved regions between the eubacterial and first halobacterial phototaxis transducer gene htrI. On the basis of the comparison of the predicted structural domains of these transducers, we propose that at least three distinct subfamilies of transducers exist in the Archaeon H. salinarium: (i) a eubacterial chemotaxis transducer type with two hydrophobic membrane-spanning segments connecting sizable domains in the periplasm and cytoplasm; (ii) a cytoplasmic domain and two or more hydrophobic transmembrane segments without periplasmic domains; and (iii) a cytoplasmic domain without hydrophobic transmembrane segments. We fractionated the halobacterial cell lysate into soluble and membrane fractions and localized different halobacterial methyl-accepting taxis proteins in both fractions.
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