ArticleProceedings of the National Academy of Sciences of the United States of America1996
The platelet-derived growth factor alpha-receptor is encoded by a growth-arrest-specific (gas) gene.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 56 citations in OpenAlex.
- Growth arrest-specific protein 7 regulates the murine M1 alveolar macrophage polarization.Immunologic research · 2017Article
- Mutations in ARMC9, which Encodes a Basal Body Protein, Cause Joubert Syndrome in Humans and Ciliopathy Phenotypes in Zebrafish.American journal of human genetics · 2017Article
- Primary Cilia and Coordination of Receptor Tyrosine Kinase (RTK) and Transforming Growth Factor β (TGF-β) Signaling.Cold Spring Harbor perspectives in biology · 2017Review
- Extracellular Signal-Regulated Kinase 2 and CHOP Restrict the Expression of the Growth Arrest-Specific p20K Lipocalin Gene to G0.Molecular and cellular biology · 2016Article
- Growth-arrest-specific 7C protein inhibits tumor metastasis via the N-WASP/FAK/F-actin and hnRNP U/β-TrCP/β-catenin pathways in lung cancer.Oncotarget · 2015Article
- Ciliary transport regulates PDGF-AA/αα signaling via elevated mammalian target of rapamycin signaling and diminished PP2A activity.Molecular biology of the cell · 2015Article
- Onward from the cradle.Molecular biology of the cell · 2014Article
- Article
- Primary cilia and coordination of receptor tyrosine kinase (RTK) signalling.The Journal of pathology · 2012Review
- Cell death or survival promoted by alternative isoforms of ErbB4.Molecular biology of the cell · 2010Article
- Gas7 functions with N-WASP to regulate the neurite outgrowth of hippocampal neurons.The Journal of biological chemistry · 2010Article
- Directional cell migration and chemotaxis in wound healing response to PDGF-AA are coordinated by the primary cilium in fibroblasts.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2010Article
- Platelet-derived growth factor-receptor alpha strongly inhibits melanoma growth in vitro and in vivo.Neoplasia (New York, N.Y.) · 2009Article
- The Na+/H+ exchanger NHE1 is required for directional migration stimulated via PDGFR-alpha in the primary cilium.The Journal of cell biology · 2009Article
- Platelet-derived growth factor-B gene delivery sustains gingival fibroblast signal transduction.Journal of periodontal research · 2008Article
- A gene-trap strategy identifies quiescence-induced genes in synchronized myoblasts.Journal of biosciences · 2008Article
- The SPARC-related factor SMOC-2 promotes growth factor-induced cyclin D1 expression and DNA synthesis via integrin-linked kinase.Molecular biology of the cell · 2008Article
- A subunit of the dynein regulatory complex in Chlamydomonas is a homologue of a growth arrest-specific gene product.The Journal of cell biology · 2003Article
- Adenoviral gene transfer of PDGF downregulates gas gene product PDGFalphaR and prolongs ERK and Akt/PKB activation.American journal of physiology. Cell physiology · 2002Article
- Characterization of a novel quiescence responsive element downregulated by v-Src in the promoter of the neuroretina specific QR1 gene.Oncogene · 2000Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using the Escherichia coli lacZ gene to identify chromosomal loci that are transcriptionally active during growth arrest of NIH 3T3 fibroblasts, we found that an mRNA expressed preferentially in serum-deprived cells specifies the previously characterized alpha-receptor (alphaR) for platelet-derived growth factor (PDGF), which mediates mitogenic responsiveness to all PDGF isoforms. Both PDGFalphaR mRNA, which was shown to include a 111-nt segment encoded by a DNA region thought to contain only intron sequences, and PDGFalphaR protein accumulated in serum-starved cells and decreased as cells resumed cycling. Elevated PDGFalphaR gene expression during serum starvation was not observed in cells that had been transformed with oncogenes erbB2, src, or raf, which prevent starvation-induced growth arrest. Our results support the view that products of certain genes expressed during growth arrest function to promote, rather than restrict, cell cycling. We suggest that accumulation of the PDGFalphaR gene product may facilitate the exiting of cells from growth arrest upon mitogenic stimulation by PDGF, leading to the state of "competence" required for cell cycling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.