ReviewProceedings of the National Academy of Sciences of the United States of America1996
Onconeural antigens and the paraneoplastic neurologic disorders: at the intersection of cancer, immunity, and the brain.
Review in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02533895 (Monocyte-derived Dendritic Cells Loaded With Tumour Cell Lysates for the Treatment of Refractory Solid Tumours of Childhood), which is not on this map. Cited by 91 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Monocyte-derived Dendritic Cells Loaded With Tumour Cell Lysates for the Treatment of Refractory Solid Tumours of Childhood
Who cites it
91 citing papers in PubMed, 1 synthesis or guideline pooled it, 283 citations in OpenAlex.
- Serum Tumor Markers in Paraneoplastic Neurologic Syndromes: A Systematic Review of Guidelines.Frontiers in neurology · 2020Pooled it
- Harnessing naturally occurring tumor immunity: a clinical vaccine trial in prostate cancer.PloS one · 2010Trial
- Immunization of metastatic breast cancer patients with a fully synthetic globo H conjugate: a phase I trial.Proceedings of the National Academy of Sciences of the United States of America · 2001Trial
- Application and mechanistic research of novel therapeutic strategies in cisplatin-resistant small cell lung cancer.Annals of medicine · 2026Review
- Article
- Anti-kelch-like protein 11 antibody-associated encephalitis: two case reports and literature review.BMC neurology · 2025Review
- NOVA1 acts as an oncogenic RNA-binding protein to regulate cholesterol homeostasis in human glioblastoma cells.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Lung cancer immunotherapy: progress, pitfalls, and promises.Molecular cancer · 2023Review
- Rapid-onset paraneoplastic cerebellar degeneration successfully treated by radiotherapy and tumorectomy.International cancer conference journal · 2023Article
- Paraneoplastic neurological syndrome: growing spectrum and relevance.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Review
- Persistent pain and numbness in the extremities of an adult due to paraneoplastic peripheral neuropathy caused by olfactory neuroblastoma: A case report.Frontiers in neurology · 2022Article
- Breast cancer-associated opsoclonus-myoclonus syndrome: a case report.World journal of surgical oncology · 2021Article
- Cerebellar ataxia and myeloradiculopathy associated with AP3B2 antibody: a case report and literature review.Journal of neurology · 2021Review
- Prevalence, trends, and outcomes of atrial fibrillation in hospitalized patients with metastatic cancer: findings from a national sample.Cancer medicine · 2021Article
- A Rare Coexistence of Paraneoplastic Cerebellar Degeneration: Papillary Thyroid Carcinoma.Current oncology (Toronto, Ont.) · 2021Article
- Paraneoplastic neurological syndromes: clinical presentations and management.Therapeutic advances in neurological disorders · 2021Review
- Paraneoplastic syndromes in cholangiocarcinoma.World journal of hepatology · 2020Review
- Fallopian tube serous adenocarcinoma with dizziness as the initial symptom: a case report.The Journal of international medical research · 2020Article
- Immunological Bases of Paraneoplastic Cerebellar Degeneration and Therapeutic Implications.Frontiers in immunology · 2020Review
- Insights Into Lung Cancer Immune-Based Biology, Prevention, and Treatment.Frontiers in immunology · 2020Review
31 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Paraneoplastic neurologic disorders (PNDs) are believed to be autoimmune neuronal degenerations that develop in some patients with systemic cancer. A series of genes encoding previously undiscovered neuronal proteins have been cloned using antiserum from PND patients. Identification of these onconeural antigens suggests a reclassification of the disorders into four groups: those in which neuromuscular junction proteins, nerve terminal/vesicle-associated proteins, neuronal RNA binding proteins, or neuronal signal-transduction proteins serve as target antigens. This review considers insights into basic neurobiology, tumor immunology, and autoimmune neuronal degeneration offered by the characterization of the onconeural antigens.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.