ReviewDie Naturwissenschaften1996
Embryonic angiogenesis: a review.
Review in Die Naturwissenschaften, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Macrophage induces angiogenesis via HIF signaling in denervated muscle following nerve injury.Scientific reports · 2025Article
- Chick Chorioallantoic Membrane as an in vivo Model for the Study of Angiogenesis and Lymphangiogenesis.Journal of vascular research · 2025Review
- Article
- The lymphatic vascular system: much more than just a sewer.Cell & bioscience · 2022Review
- Prospects for Manipulation of Mesenchymal Stem Cells in Tumor Therapy: Anti-Angiogenesis Property on the Spotlight.International journal of stem cells · 2021Review
- Mesenchymal stem cells and cancer therapy: insights into targeting the tumour vasculature.Cancer cell international · 2021Review
- Resistance to Anti-angiogenic Therapies: A Mechanism Depending on the Time of Exposure to the Drugs.Frontiers in cell and developmental biology · 2020Review
- New Insights Into Implementation of Mesenchymal Stem Cells in Cancer Therapy: Prospects for Anti-angiogenesis Treatment.Frontiers in oncology · 2019Review
- Role of Semaphorin Signaling During Cardiovascular Development.Journal of the American Heart Association · 2018Review
- Etv2 as an essential regulator of mesodermal lineage development.Cardiovascular research · 2017Review
- Computational flow dynamics in a geometric model of intussusceptive angiogenesis.Microvascular research · 2009Article
- Therapeutic angiogenesis in cardiovascular disease.Journal of cardiothoracic surgery · 2007Review
- Transitions in cell organization and in expression of contractile and extracellular matrix proteins during development of chicken aortic smooth muscle: evidence for a complex spatial and temporal differentiation program.Anatomy and embryology · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Supply with nutrients is essential from early embryonic stages onwards. Therefore, circulatory organs form the first functioning organ system. With the exception of the heart, this system is at first formed by only one cell type, the endothelial cell. Emergence, behavior, and differentiation of endothelial cells are discussed in this review. At first, endothelial cells develop from angioblasts (primary angiogenesis/angioblastic development), later they develop from preexisting endothelial cells (secondary angiogenesis/angiotrophic growth). The composition of the extracellular matrix may promote or inhibit angiogenesis. Various growth factors which can be bound to the extracellular matrix may have been found, but only two of them (VEGF, P1GF) seem to influence endothelial cell behavior directly. Heterogeneity and organ-typical differentiation of endothelial cells seem to be dependent on cell-cell signaling within each organ.
Indexed as
Identifiers
8643122What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.