ArticleJournal of virology1996
Retroviral insertional activation in a herpesvirus: transcriptional activation of US genes by an integrated long terminal repeat in a Marek's disease virus clone.
Article in Journal of virology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 82 citations in OpenAlex.
- Onset and long-term duration of immunity provided by a single vaccination with recombinant a Marek's disease virus with REV-LTR insertion.Frontiers in veterinary science · 2024Article
- Out of Sight, but Not Out of Mind: Aspects of the Avian Oncogenic Herpesvirus, Marek's Disease Virus.Animals : an open access journal from MDPI · 2020Review
- Article
- Increased Horizontal Transmission of Recombinant Marek's Disease Virus Due to Reticuloendotheliosis Virus Long Terminal Repeat Is the Major Competitive Advantage of the Virus Being a Prevalent Strain.Frontiers in microbiology · 2019Article
- Characterization of a Gallid herpesvirus 2 strain with novel reticuloendotheliosis virus long terminal repeat inserts.Virus genes · 2017Article
- Analysis of the spleen proteome of chickens infected with reticuloendotheliosis virus.Archives of virology · 2017Article
- Transcriptional and Bioinformatic Analysis Provide a Relationship between Host Response Changes to Marek's Disease Viruses Infection and an Integrated Long Terminal Repeat.Frontiers in cellular and infection microbiology · 2016Article
- Article
- Molecular characteristics of Polish field strains of Marek's disease herpesvirus isolated from vaccinated chickens.Acta veterinaria Scandinavica · 2011Article
- Horizontal gene transfers with or without cell fusions in all categories of the living matter.Advances in experimental medicine and biology · 2011Review
- Molecular and biological characterization of a Marek's disease virus field strain with reticuloendotheliosis virus LTR insert.Virus genes · 2010Article
- Sequence determination of a mildly virulent strain (CU-2) of Gallid herpesvirus type 2 using 454 pyrosequencing.Virus genes · 2008Article
- Creation of diversity in the animal virus world by inter-species and intra-species recombinations: lessons learned from poultry viruses.Virus genes · 2008Review
- Article
- Growth hormone interacts with the Marek's disease virus SORF2 protein and is associated with disease resistance in chicken.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- The genome of turkey herpesvirus.Journal of virology · 2001Article
- The genome of a very virulent Marek's disease virus.Journal of virology · 2000Article
- The complete unique long sequence and the overall genomic organization of the GA strain of Marek's disease virus.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Poxvirus homologues of cellular genes.Virus genes · 2000Review
- Insertion of tandem direct repeats consisting of avian leukosis virus LTR sequences into the inverted repeat region of Marek's disease virus type 1 DNA.Virus genes · 1997Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Insertional activation of host proto-oncogenes has been recognized as a basic mechanism by which nonacute retroviruses induce cancer. Our previous work has demonstrated that retroviruses can efficiently integrate into DNA virus genomes. Specifically, coinfection of cultured fibroblasts with a chicken herpesvirus, Marek's disease virus (MDV), and a chicken retrovirus results in frequent stable retroviral insertions into the herpesvirus genome. Such insertions could alter the expression of herpesvirus genes, possibly resulting in novel phenotypic properties. In this article, we report the characterization of a replication-competent clone of MDV with integrated retroviral sequences. This virus was isolated from a chicken following injection of fibroblasts coinfected with MDV and the retrovirus, reticuloendotheliosis virus. Transcripts originating from the reticuloendotheliosis virus long terminal repeat promoters were found to encode the adjoining MDV genes, SORF2, US1, and US10. This virus replicates well in culture but has an unusual phenotype in chickens, characterized by an attenuated virulence which produces no nerve lesions but, rather, severe thymic atrophy. While the causal relationship between the insertion and the observed phenotypes remains to be established, our data provide the first evidence of retroviral insertional activation of herpesvirus genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.