ArticleThe Journal of experimental medicine1996
An autosomal dominant locus, Nka, mapping to the Ly-49 region of a rat natural killer (NK) gene complex, controls NK cell lysis of allogeneic lymphocytes.
Article in The Journal of experimental medicine, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 117 citations in OpenAlex.
- Recognition ofInnate immunity · 2023Review
- Recent Advances in Molecular Mechanisms of the NKG2D Pathway in Hepatocellular Carcinoma.Biomolecules · 2020Review
- Identification of MHC Class Ib Ligands for Stimulatory and Inhibitory Ly49 Receptors and Induction of Potent NK Cell Alloresponses in Rats.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Nkrp1 family, from lectins to protein interacting molecules.Molecules (Basel, Switzerland) · 2015Article
- The early days of NK cells: an example of how a phenomenon led to detection of a novel immune receptor system - lessons from a rat model.Frontiers in immunology · 2014Review
- Complexity and Diversity of the NKR-P1:Clr (Klrb1:Clec2) Recognition Systems.Frontiers in immunology · 2014Review
- Paired opposing leukocyte receptors recognizing rapidly evolving ligands are subject to homogenization of their ligand binding domains.Immunogenetics · 2011Article
- Structural analysis of natural killer cell receptor protein 1 (NKR-P1) extracellular domains suggests a conserved long loop region involved in ligand specificity.Journal of molecular modeling · 2011Article
- The complete inventory of receptors encoded by the rat natural killer cell gene complex.Immunogenetics · 2010Article
- Identification of the rat NKG2D ligands, RAE1L and RRLT, and their role in allograft rejection.European journal of immunology · 2010Article
- Strain-dependent expression of four structurally related rat Ly49 receptors; correlation with NK gene complex haplotype and NK alloreactivity.Immunogenetics · 2006Article
- Molecular cloning of KLRI1 and KLRI2, a novel pair of lectin-like natural killer-cell receptors with opposing signalling motifs.Immunogenetics · 2005Article
- Identification of lectin-like receptors expressed by antigen presenting cells and neutrophils and their mapping to a novel gene complex.Immunogenetics · 2004Article
- Genomic organization and evolutionary analysis of Ly49 genes encoding the rodent natural killer cell receptors: rapid evolution by repeated gene duplication.Immunogenetics · 2004Article
- Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- A single major chromosomal region controls natural killer cell-like activity in rainbow trout.Immunogenetics · 2004Article
- Ly49Q, a member of the Ly49 family that is selectively expressed on myeloid lineage cells and involved in regulation of cytoskeletal architecture.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- The lectin-like receptor KLRE1 inhibits natural killer cell cytotoxicity.The Journal of experimental medicine · 2003Article
- Ly49 genes in non-rodent mammals.Immunogenetics · 2003Article
- Immune functions encoded by the natural killer gene complex.Nature reviews. Immunology · 2003Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Natural Killer (NK) cells can recognize and kill MHC-incompatible normal bone marrow-derived cells. Presently characterized MHC-binding receptors on NK cells, including the Ly-49 family in the mouse, transmit inhibitory signals upon binding to cognate class I MHC ligands. Here we study in vivo NK-mediated lysis of normal allogeneic lymphocytes in crosses between alloreactivity-competent PVG rats and alloreactivity-deficient DA rats. NK cells from both strains are able to lyse standard tumor targets. We identify an autosomal dominant locus, Nka, that controls NK-mediated alloreactivity. Individuals carrying the dominant PVG allele in single dose were fully competent in eliminating allogeneic target cells, suggesting that Nka encodes or regulates a gene product inducing or activating alloreactivity. By linkage analysis and pulsed field gel electrophoresis, a natural killer gene complex (NKC) on rat chromosome 4 is described that contains the rat NKR-P1 and Ly-49 multigene families plus a rat NKG2D homologue. Nka maps within the NKC, together with the most telomeric Ly-49 family members, but separate from NKG2D and the NKR-P1 family. The Nka-encoded response, moreover, correlates with the expression of transcripts for Ly-49 receptors in NK cell populations, as Northern blot analysis demonstrated low expression of Ly-49 genes in DA NK cells, in contrast to high expression in alloreactivity-competent PVG, (DA X PVG)F1, and PVG.1AVI NK cells. The low Ly-49 expression in DA is not induced by MHC haplotype, as demonstrated by high expression of Ly-49 in the DA MHC-congenic PVG.1AVI strain. Finally, we have cloned and characterized the first four members of the rat Ly-49 gene family. Their cytoplasmic domains demonstrate substantial heterogeneity, consistent with the hypothesis that different Ly-49 family members may subserve different signaling functions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.