ArticleThe Journal of experimental medicine1996
Expression of variants of the major surface glycoprotein of Pneumocystis carinii.
Article in The Journal of experimental medicine, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 55 citations in OpenAlex.
- Selective expression ofmBio · 2025Article
- Retracing the evolution ofMicrobiology and molecular biology reviews : MMBR · 2024Review
- The trophic life cycle stage of Pneumocystis species induces protective adaptive responses without inflammation-mediated progression to pneumonia.Medical mycology · 2018Article
- A Molecular Window into the Biology and Epidemiology of Pneumocystis spp.Clinical microbiology reviews · 2018Review
- The Interaction ofJournal of immunology (Baltimore, Md. : 1950) · 2017Article
- Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.Nature communications · 2016Article
- Microbial antigenic variation mediated by homologous DNA recombination.FEMS microbiology reviews · 2012Review
- Chitinases in Pneumocystis carinii pneumonia.Medical microbiology and immunology · 2012Article
- Discordant antibody and cellular responses to Pneumocystis major surface glycoprotein variants in mice.BMC immunology · 2012Article
- Galleria mellonella are resistant to Pneumocystis murina infection.Mycopathologia · 2011Article
- Evidence for high prevalence of Pneumocystis jirovecii exposure among Cameroonians.Acta tropica · 2009Article
- Complexity of the MSG gene family of Pneumocystis carinii.BMC genomics · 2009Article
- Variation in the major surface glycoprotein genes in Pneumocystis jirovecii.The Journal of infectious diseases · 2008Article
- Pneumocystis encodes a functional S-adenosylmethionine synthetase gene.Eukaryotic cell · 2008Article
- Pneumocystis murina MSG gene family and the structure of the locus associated with its transcription.Fungal genetics and biology : FG & B · 2007Article
- Gene arrays at Pneumocystis carinii telomeres.Genetics · 2005Article
- Heterogeneity of Pneumocystis sterol profiles of samples from different sites in the same pair of lungs suggests coinfection by distinct organism populations.Journal of clinical microbiology · 2001Article
- Genetics of surface antigen expression in Pneumocystis carinii.Infection and immunity · 2001Review
- Immunological features of Pneumocystis carinii infection in humans.Clinical and diagnostic laboratory immunology · 1999Review
- Characterization of major surface glycoprotein genes of human Pneumocystis carinii and high-level expression of a conserved region.Infection and immunity · 1998Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previously, we have shown that a multicopy family of related but unique genes encodes the major surface glycoprotein (MSG) of Pneumocystis carinii. To examine whether different members of this gene family are expressed by P. carinii, antisera were prepared against peptides whose sequences were determined from the deduced amino acid sequences of variants of rat-derived MSG. Immunohistochemical staining of serial sections of rat lungs of infected animals showed that at least three variants of MSG were expressed in an individual lobe, that there was a focal expression of these variants within the lung, and that the relative numbers of these foci were different. Indirect immunofluorescent staining of purified P. carinii organisms using these antisera revealed that at least three variants of MSG were present in organisms isolated from an individual rat and that both cysts and trophozoites reacted with each antiserum. A substantial difference in the fraction of organisms reacting with a specific antipeptide antiserum was seen when comparing organisms isolated from rats raised in a single colony over a period of two years as well as organisms isolated at one time point from rats raised in different colonies. This demonstration of antigenic variation in P. carinii supports the hypothesis that P. carinii utilizes such variation for evading host defense mechanisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.