ArticleThe Journal of experimental medicine1996
Genetic control of the frequency of hematopoietic stem cells in mice: mapping of a candidate locus to chromosome 1.
Article in The Journal of experimental medicine, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed.
- Glycolysis-Optimized Conditions Enhance Maintenance of Regenerative Integrity in Mouse Spermatogonial Stem Cells during Long-Term Culture.Stem cell reports · 2017Article
- Myc/Mycn-mediated glycolysis enhances mouse spermatogonial stem cell self-renewal.Genes & development · 2016Article
- The Genetic Landscape of Hematopoietic Stem Cell Frequency in Mice.Stem cell reports · 2015Article
- Article
- Changes in primary lymphoid organs with aging.Seminars in immunology · 2012Review
- Article
- A quantitative trait locus on chr.4 regulates thymic involution.The journals of gerontology. Series A, Biological sciences and medical sciences · 2010Article
- Stem cell aging: survival of the laziest?Cell cycle (Georgetown, Tex.) · 2008Review
- A quantitative trait locus on chromosome 4 affects cycling of hematopoietic stem and progenitor cells through regulation of TGF-beta 2 responsiveness.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Combining transcriptional profiling and genetic linkage analysis to uncover gene networks operating in hematopoietic stem cells and their progeny.Immunogenetics · 2008Review
- Article
- QTL analyses of lineage-negative mouse bone marrow cells labeled with Sca-1 and c-Kit.Mammalian genome : official journal of the International Mammalian Genome Society · 2008Article
- Distributions of single nucleotide polymorphisms in differential chromosome segments of congenic resistant strains that define minor histocompatibility antigens.Immunogenetics · 2007Article
- Analysis of expansion of myeloid progenitors in mice to identify leukemic susceptibility genes.Mammalian genome : official journal of the International Mammalian Genome Society · 2006Article
- QTL influencing baseline hematocrit in the C57BL/6J and DBA/2J lineage: age-related effects.Mammalian genome : official journal of the International Mammalian Genome Society · 2006Article
- The hematopoietic stem compartment consists of a limited number of discrete stem cell subsets.Blood · 2006Article
- Article
- Senescence of hematopoietic stem cells and bone marrow failure.International journal of hematology · 2005Review
- Effects of aging on the homing and engraftment of murine hematopoietic stem and progenitor cells.Blood · 2005Article
- Regulation of hematopoietic stem cell aging in vivo by a distinct genetic element.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The genetic elements that govern the differentiation and proliferation of hematopoietic stem cells remain to be defined. We describe here marked strain-specific differences in the frequency of long-term culture-initiating cells (LTC-IC) in the bone marrow of different strains of mice. Mice of C57Bl/6 background showed the lowest levels of stem cells in marrow, averaging 2.4 +/- .06 LTC-IC/10(5) cells, BALB/c is intermediate (9.1 +/- 4.2/10(5) cells), and DBA/2 mice contained a 11-fold higher frequency of LTC-IC (28.1 +/- 16.5/10(5) cells) than C57Bl/6 mice. The genetic factors affecting the size of the stem cell pool were analyzed in the C57Bl/6 X DBA/2 recombinant inbred strains; LTC-IC frequencies ranged widely, indicating that stem cell frequencies are controlled by multiple genes. Quantitative trait linkage analysis suggested that two loci that have major quantitative effects are located on chromosome 1 near Adprp and Acrg, respectively. The mapping of the locus near Adprp was confirmed by finding an elevated stem cell frequency in B6.C-H25, a C57Bl/6 congenic strain that carries a portion of chromosome 1 derived from BALB/c mice. We have named this gene Scfr1 (stem cell frequency regulator 1). The allelic forms of this gene may be an important predictor of stem cell number and thus would be useful for evaluating cell sources in clinical stem cell transplantation.
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