ArticleThe Journal of experimental medicine1996
Expansion of cytokine-producing CD4-CD8- T cells associated with abnormal Fas expression and hypereosinophilia.
Article in The Journal of experimental medicine, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 148 citations in OpenAlex.
- Mepolizumab as a corticosteroid-sparing agent in lymphocytic variant hypereosinophilic syndrome.The Journal of allergy and clinical immunology · 2010Trial
- [Efficacy and survival outcomes of patients with lymphocytic variant hypereosinophilic syndrome].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2025Article
- Pirin Inhibits FAS-Mediated Apoptosis to Support Colorectal Cancer Survival.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Novel targeted therapies for eosinophil-associated diseases and allergy.Annual review of pharmacology and toxicology · 2015Review
- NIK prevents the development of hypereosinophilic syndrome-like disease in mice independent of IKKα activation.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Clinical overview of cutaneous features in hypereosinophilic syndrome.Current allergy and asthma reports · 2012Review
- A patient with hypereosinophilic syndrome that manifested with acquired hemophilia and elevated IgG4: a case report.Journal of medical case reports · 2012Article
- Hypereosinophilic syndrome variants: diagnostic and therapeutic considerations.Haematologica · 2009Review
- Idiopathic hypereosinophilic syndrome with skull base involvement.AJNR. American journal of neuroradiology · 2007Article
- Altered cytokine expression in mesenteric lymph nodes in a rat strain (Matsumoto Eosinophilic Shinshu) that spontaneously develops hypereosinophilia.Immunology · 2005Article
- Identification of T-cell epitopes on U1A protein in MRL/lpr mice: double-negative T cells are the major responsive cells.Immunology · 2005Article
- Proinflammatory cytokines (IL-17, IL-6, IL-18 and IL-12) and Th cytokines (IFN-gamma, IL-4, IL-10 and IL-13) in patients with allergic asthma.Clinical and experimental immunology · 2001Article
- Cytokine-mediated Bax deficiency and consequent delayed neutrophil apoptosis: a general mechanism to accumulate effector cells in inflammation.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Involvement of soluble CD95 in Churg-Strauss syndrome.The American journal of pathology · 1999Article
- Disruption of fas receptor signaling by nitric oxide in eosinophils.The Journal of experimental medicine · 1998Article
- Clinical effects of mutations to CD95 (Fas): relevance to autoimmunity?Springer seminars in immunopathology · 1998Review
- Fas and the art of lymphocyte maintenance.The Journal of experimental medicine · 1996Review
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanisms of sustained overproduction of eosinophils in the idiopathic hypereosinophilic syndrome and in some human immunodeficiency virus (HIV)-1-infected individuals are largely unknown. We hypothesized that T cells may release soluble products that regulate eosinophilia in these patients, as has been previously shown in bronchial asthma. We identified one patient with idiopathic hypereosinophilic syndrome and one HIV-1-infected individual with associated hypereosinophilia who demonstrated high numbers of CD4-CD8- T cells in peripheral blood. CD4-CD8- T cells from both patients, although highly activated, did not express functional Fas receptors. In one case, the lack of functional Fas receptors was associated with failure of Fas mRNA and protein expression, and in another, expression of a soluble form of the Fas molecule that may have antagonized normal signaling of Fas ligand. In contrast to the recently described lymphoproliferative/autoimmune syndrome, which is characterized by accumulation of CD4-CD8- T cells and mutations within the Fas gene, this study suggests somatic variations in Fas expression and function quite late in life. Both genetic and somatic abnormalities in regulation of the Fas gene are therefore associated with failures to undergo T cell apoptosis. Furthermore, the expanded population of CD4-CD8- T cells from both patients elaborated cytokines with antiapoptotic properties for eosinophils, indicating a major role of these T cells in the development of eosinophilia. Thus, this study demonstrates a sequential dysregulation of apoptosis in different cell types.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.