ArticleInfection and immunity1996
Blood group glycolipids as epithelial cell receptors for Candida albicans.
Article in Infection and immunity, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 49 citations in OpenAlex.
- Microbial lectome versus host glycolipidome: How pathogens exploit glycosphingolipids to invade, dupe or kill.Frontiers in microbiology · 2022Review
- The Potential Contribution of ABO, Lewis and Secretor Histo-Blood Group Carbohydrates in Infection byFrontiers in cellular and infection microbiology · 2021Article
- Blood group antigen expression is involved in C. albicans interaction with buccal epithelial cells.Glycoconjugate journal · 2017Article
- Blood Groups in Infection and Host Susceptibility.Clinical microbiology reviews · 2015Review
- A comparative study of Candida albicans mean colony counts and blood group antigens in the saliva of healthy subjects.Dental research journal · 2014Article
- Cervical mucins carry alpha(1,2)fucosylated glycans that partly protect from experimental vaginal candidiasis.Glycoconjugate journal · 2009Article
- Gastrointestinal mucins of Fut2-null mice lack terminal fucosylation without affecting colonization by Candida albicans.Glycobiology · 2005Article
- Virulence of the fungal pathogen Candida albicans requires the five isoforms of protein mannosyltransferases.Infection and immunity · 2005Article
- Increased susceptibility of secretor factor gene Fut2-null mice to experimental vaginal candidiasis.Infection and immunity · 2004Article
- Beta-1,2- and alpha-1,2-linked oligomannosides mediate adherence of Candida albicans blastospores to human enterocytes in vitro.Infection and immunity · 2003Article
- Synthetic analogues of beta-1,2 oligomannosides prevent intestinal colonization by the pathogenic yeast Candida albicans.Antimicrobial agents and chemotherapy · 2002Article
- Characterization of binding of Candida albicans to small intestinal mucin and its role in adherence to mucosal epithelial cells.Infection and immunity · 2000Article
- Cell wall and secreted proteins of Candida albicans: identification, function, and expression.Microbiology and molecular biology reviews : MMBR · 1998Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of glycosphingolipids as possible epithelial cell receptors for Candida albicans was examined by investigating the binding of biotinylated yeasts to lipids extracted from human buccal epithelial cells and separated on thin-layer chromatograms. Binding was visualized by the addition of 125I-streptavidin followed by autoradiography. Five C. albicans strains thought from earlier work to have a requirement for fucose-containing receptors all bound to the same three components in the lipid extract. A parallel chromatogram overlaid with biotinylated Ulex europaeus lectin, which is a fucose-binding lectin with a specificity for the H blood group antigen, showed that two of these glycosphingolipids carried this antigenic determinant. Preparations of crude and purified adhesin (a protein with a size of 15.7 kDa which lacked cysteine residues) from one of the strains also bound to these same two components. The third glycosphingolipid, which bound whole cells but neither preparation of adhesin, was recognized by Helix pomatia lectin, indicating that it contained N-acetylgalactosamine, possibly in the form of the A blood group antigen. Overlay assays with a sixth strain of C. albicans (GDH 2023) revealed a completely different binding pattern of four receptors, each of which contained N-acetylglucosamine. These results confirm earlier predictions about the receptor specificity of the strains made on the basis of adhesion inhibition studies and indicate that blood group antigens can act as epithelial cell receptors for C. albicans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.