ArticleHuman genetics1996
Allelic loss of the short arm of chromosome 4 in neuroblastoma suggests a novel tumour suppressor gene locus.
Article in Human genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 58 citations in OpenAlex.
- Genomic Analysis Made It Possible to Identify Gene-Driver Alterations Covering the Time Window between Diagnosis of Neuroblastoma 4S and the Progression to Stage 4.International journal of molecular sciences · 2022Article
- Bioinformatics analysis of recurrent deletion regions in neuroblastoma.Medical oncology (Northwood, London, England) · 2022Article
- Biomarkers in Neuroblastoma: An Insight into Their Potential Diagnostic and Prognostic Utilities.Current treatment options in oncology · 2021Review
- Ultra-High Density SNParray in Neuroblastoma Molecular Diagnostics.Frontiers in oncology · 2014Article
- The connections between neural crest development and neuroblastoma.Current topics in developmental biology · 2011Review
- International consensus for neuroblastoma molecular diagnostics: report from the International Neuroblastoma Risk Group (INRG) Biology Committee.British journal of cancer · 2009Article
- Comparison of different techniques for the detection of genetic risk-identifying chromosomal gains and losses in neuroblastoma.Virchows Archiv : an international journal of pathology · 2008Article
- Are there tumor suppressor genes on chromosome 4p in sporadic colorectal carcinoma?World journal of gastroenterology · 2008Article
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- Region-specific detection of neuroblastoma loss of heterozygosity at multiple loci simultaneously using a SNP-based tag-array platform.Genome research · 2005Article
- Article
- SLIT2 promoter methylation analysis in neuroblastoma, Wilms' tumour and renal cell carcinoma.British journal of cancer · 2004Article
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- Neuroblastoma tumour genetics: clinical and biological aspects.Journal of clinical pathology · 2001Review
- RNF4 is a growth inhibitor expressed in germ cells but not in human testicular tumors.The American journal of pathology · 2001Article
- Neuroblastomas with chromosome 11q loss and single copy MYCN comprise a biologically distinct group of tumours with adverse prognosis.British journal of cancer · 2001Article
- Loss of heterozygosity at 4p16.3 and mutation of FGFR3 in transitional cell carcinoma.Oncogene · 2001Article
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- Loss of heterozygosity of 3p markers in neuroblastoma tumours implicate a tumour-suppressor locus distal to the FHIT gene.British journal of cancer · 1998Article
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuroblastoma is a childhood neural crest tumour, genetically characterized by frequent deletions of the short arm of chromosome 1 and amplification of N-myc. Here we report the first evidence for a neuroblastoma tumour suppressor locus on 4pter. Cytogenetically we demonstrated rearrangements of 4p in 7 out of 26 evaluable tumours (27%). Subsequent analysis of loss of heterozygosity (LOH) by Southern blotting revealed allelic loss of 4p in 16/82 (19.5%) informative neuroblastomas. Taken together cytogenetic and Southern blot analyses showed loss of 4p in 20/86 neuroblastomas analysed (23%). The common deleted region was bordered by the probe D4S123 and encompassed the distal 34 cM of 4p. We found no evidence for genomic imprinting of the 4p locus as the 4p alleles lost in the tumours were of random maternal and paternal origin. LOH4p was found at all disease stages and in every age group. Furthermore LOH4p was present both in cases with and without LOH1p and amplification of N-myc.
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