ArticleThe EMBO journal1996
Transfer of rps19 to the nucleus involves the gain of an RNP-binding motif which may functionally replace RPS13 in Arabidopsis mitochondria.
Article in The EMBO journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 66 citations in OpenAlex.
- Comparative mitochondrial genomics of Terniopsis yongtaiensis in Malpighiales: structural, sequential, and phylogenetic perspectives.BMC genomics · 2024Article
- Origin of minicircular mitochondrial genomes in red algae.Nature communications · 2023Article
- The complete plastid genome of Cotinus coggygria and phylogenetic analysis of the Anacardiaceae.Genetics and molecular biology · 2021Article
- Retention of functional genes for S19 ribosomal protein in both the mitochondrion and nucleus for over 60 million years.Molecular genetics and genomics : MGG · 2015Article
- Article
- Reconstructing the evolution of the mitochondrial ribosomal proteome.Nucleic acids research · 2007Article
- Adaptations required for mitochondrial import following mitochondrial to nucleus gene transfer of ribosomal protein S10.Plant physiology · 2005Article
- Fate of mitochondrially located S19 ribosomal protein genes after transfer of a functional copy to the nucleus in cereals.Molecular genetics and genomics : MGG · 2005Article
- A novel additional group II intron distinguishes the mitochondrial rps3 gene in gymnosperms.Journal of molecular evolution · 2005Article
- The mitochondrial DNA of land plants: peculiarities in phylogenetic perspective.Current genetics · 2004Review
- Abundance of plastid DNA insertions in nuclear genomes of rice and Arabidopsis.Plant molecular biology · 2003Article
- Nuclear genes that encode mitochondrial proteins for DNA and RNA metabolism are clustered in the Arabidopsis genome.The Plant cell · 2003Article
- Plant mitochondrial rps2 genes code for proteins with a C-terminal extension that is processed.Plant molecular biology · 2002Article
- Punctuated evolution of mitochondrial gene content: high and variable rates of mitochondrial gene loss and transfer to the nucleus during angiosperm evolution.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- A family of RRM-type RNA-binding proteins specific to plant mitochondria.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Genes for two mitochondrial ribosomal proteins in flowering plants are derived from their chloroplast or cytosolic counterparts.The Plant cell · 2002Article
- Genome analysis: RNA recognition motif (RRM) and K homology (KH) domain RNA-binding proteins from the flowering plant Arabidopsis thaliana.Nucleic acids research · 2002Article
- Analysis of the Arabidopsis mitochondrial proteome.Plant physiology · 2001Article
- Multiple losses and transfers to the nucleus of two mitochondrial succinate dehydrogenase genes during angiosperm evolution.Genetics · 2001Article
- Dynamic evolution of plant mitochondrial genomes: mobile genes and introns and highly variable mutation rates.Proceedings of the National Academy of Sciences of the United States of America · 2000Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The discovery of disrupted rps19 genes in Arabidopsis mitochondria prompted speculation about the transfer to the nuclear compartment. We here describe the functional gene transfer of rps19 into the nucleus of Arabidopsis. Molecular cloning and sequence analysis of rps19 show that the nuclear gene encodes a long N-terminal extension. Import studies of the precursor protein indicate that only a small part of this extension is cleaved off during import. The larger part of the extension, which shows high similarity to conserved RNA-binding domains of the RNP-CS type, became part of the S19 protein. In the Escherichia coli ribosome S19 forms an RNA-binding complex as heterodimer with S13. By using immuno-analysis and import studies we show that a eubacterial-like S13 protein is absent from Arabidopsis mitochondria, and is not substituted by either a chloroplastic or a cytosolic homologue of this ribosomal protein. We therefore propose that either a highly diverged or missing RPS13 has been functionally replaced by an RNP domain that most likely derived from a glycine-rich RNA-binding protein. These results represent the first case of a functional replacement of a ribosomal protein by a common RNA-binding domain and offer a new view on the flexibility of biological systems in using well-adapted functional domains for different jobs.
Indexed as
Identifiers
8641279PMC450136W1859256729What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.