ArticleProceedings of the National Academy of Sciences of the United States of America1996
Spontaneous avoidance behavior in Drosophila null for calmodulin expression.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 58 citations in OpenAlex.
- Lipid Metabolism in Relation to Calcium Homeostasis.Advances in experimental medicine and biology · 2026Review
- Article
- Review
- Article
- Fast intensity adaptation enhances the encoding of sound in Drosophila.Nature communications · 2018Article
- Article
- Molecular evolution of the multiple calmodulin-like cal genes in C. elegans and in nematodes.Development genes and evolution · 2016Article
- The wavy Mutation Maps to the Inositol 1,4,5-Trisphosphate 3-Kinase 2 (IP3K2) Gene of Drosophila and Interacts with IP3R to Affect Wing Development.G3 (Bethesda, Md.) · 2015Article
- Drosophila pericentrin requires interaction with calmodulin for its function at centrosomes and neuronal basal bodies but not at sperm basal bodies.Molecular biology of the cell · 2014Article
- Serotonin receptors expressed in Drosophila mushroom bodies differentially modulate larval locomotion.PloS one · 2014Article
- Hyperthermic seizures and aberrant cellular homeostasis in Drosophila dystrophic muscles.Scientific reports · 2011Article
- Intracellular calcium deficits in Drosophila cholinergic neurons expressing wild type or FAD-mutant presenilin.PloS one · 2009Article
- Phototransduction and retinal degeneration in Drosophila.Pflugers Archiv : European journal of physiology · 2007Review
- An assay of behavioral plasticity in Drosophila larvae.Journal of neuroscience methods · 2005Article
- Calcium- and calcineurin-independent roles for calmodulin in Cryptococcus neoformans morphogenesis and high-temperature growth.Eukaryotic cell · 2005Article
- Drosophila calmodulin mutants with specific defects in the musculature or in the nervous system.Genetics · 2003Article
- Calmodulin regulates synaptic plasticity in the anterior cingulate cortex and behavioral responses: a microelectroporation study in adult rodents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Calmodulin is an auxiliary subunit of KCNQ2/3 potassium channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Calcium binding is required for calmodulin function in Aspergillus nidulans.Eukaryotic cell · 2002Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The regulatory protein calmodulin is a major mediator of calcium-induced changes in cellular activity. To analyze the roles of calmodulin in an intact animal, we have generated a calmodulin null mutation in Drosophila melanogaster. Maternal calmodulin supports calmodulin null individuals throughout embryogenesis, but they die within 2 days of hatching as first instar larvae. We have detected two pronounced behavioral abnormalities specific to the loss of calmodulin in these larvae. Swinging of the head and anterior body, which occurs in the presence of food, is three times more frequent in the null animals. More strikingly, most locomotion in calmodulin null larvae is spontaneous backward movement. This is in marked contrast to the wild-type situation where backward locomotion is seen only as a stimulus-elicited avoidance response. Our finding of spontaneous avoidance behavior has striking similarities to the enhanced avoidance responses produced by some calmodulin mutations in Paramecium. Thus our results suggest evolutionary conservation of a role for calmodulin in membrane excitability and linked behavioral responses.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.