ReviewProceedings of the National Academy of Sciences of the United States of America1996
gamma/delta and other unconventional T lymphocytes: what do they see and what do they do?
Review in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
71 citing papers in PubMed.
- Vaccine development against tuberculosis before and after Covid-19.Frontiers in immunology · 2023Review
- The role of unconventional T cells in COVID-19.Irish journal of medical science · 2022Review
- The dark side of the spoon - glucose, ketones and COVID-19: a possible role for ketogenic diet?Journal of translational medicine · 2020Review
- Single-Cell Sequencing of T cell Receptors: A Perspective on the Technological Development and Translational Application.Advances in experimental medicine and biology · 2020Review
- Analysis of the Healthy Subject Response to Prolonged Contact with Tuberculosis Patients.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2019Article
- The association between adherence with oral bisphosphonates and the risk of breast cancer in post-menopausal women.Journal of bone oncology · 2019Article
- Tissue adaptation: Implications for gut immunity and tolerance.The Journal of experimental medicine · 2017Review
- IL-17 Production from T Helper 17, Mucosal-Associated Invariant T, and γδ Cells in Tuberculosis Infection and Disease.Frontiers in immunology · 2017Article
- Article
- Pro-inflammatory T-lymphocytes rapidly infiltrate into the brain and contribute to neuronal injury following cardiac arrest and cardiopulmonary resuscitation.Journal of neuroimmunology · 2014Article
- Global characterization of differential gene expression profiles in mouse Vγ1+ and Vγ4+ γδ T cells.PloS one · 2014Article
- Location, location, location: tissue-specific regulation of immune responses.Journal of leukocyte biology · 2013Review
- Epstein-Barr virus-associated lymphoid malignancies: the expanding spectrum of hematopoietic neoplasms.Nagoya journal of medical science · 2013Review
- Evaluation of the safety and immunogenicity of a candidate tuberculosis vaccine, MVA85A, delivered by aerosol to the lungs of macaques.Clinical and vaccine immunology : CVI · 2013Article
- The immunobiology of the mammalian epididymis: the black box is now open!Basic and clinical andrology · 2013Article
- Review
- Application of flow cytometric in situ hybridization assay to Epstein-Barr virus-associated T/natural killer cell lymphoproliferative diseases.Cancer science · 2012Article
- The role of T lymphocytes in cancer patients undergoing immunotherapy with autologous dendritic cells.Clinical Medicine Insights. Oncology · 2011Article
- Microbial colonization drives expansion of IL-1 receptor 1-expressing and IL-17-producing gamma/delta T cells.Cell host & microbe · 2010Article
- Adipose tissue lymphocytes: types and roles.Journal of physiology and biochemistry · 2009Review
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
T lymphocytes recognize specific ligands by clonally distributed T-cell receptors (TCR). In humans and most animals, the vast majority of T cells express a TCR composed of an alpha chain and a beta chain, whereas a minor T-cell population is characterized by the TCR gamma/delta. Almost all of our knowledge about T cells stems from alpha/beta T cells and only now are we beginning to understand gamma/delta T cells. In contrast to conventional alpha/beta T cells, which are specific for antigenic peptides presented by gene products of the major histocompatibility complex, gamma/delta T cells directly recognize proteins and even nonproteinacious phospholigands. These findings reveal that gamma/delta T cells and alpha/beta T cells recognize antigen in a fundamentally different way and hence mitigate the dogma of exclusive peptide-major histocompatibility complex recognition by T cells. A role for gamma/delta T cells in antimicrobial immunity has been firmly established. Although some gamma/delta T cells perform effector functions, regulation of the professional and the nonprofessional immune system seems to be of at least equal importance. The prominent residence of gamma/delta T cells in epithelial tissues and the rapid mobilization of gamma/delta T cells in response to infection are consistent with such regulatory activities under physiological and pathologic conditions. Thus, although gamma/delta T cells are a minor fraction of all T cells, they are not just uninfluential kin of alpha/beta T cells but have their unique raison d'être.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.