ArticleThe Journal of clinical investigation1996
Identification of clonally expanded T cells in rheumatoid arthritis using a sequence enrichment nuclease assay.
Article in The Journal of clinical investigation, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 47 citations in OpenAlex.
- Identification of human viral protein-derived ligands recognized by individual MHCI-restricted T-cell receptors.Immunology and cell biology · 2016Article
- Individual MHCI-Restricted T-Cell Receptors are Characterized by a Unique Peptide Recognition Signature.Frontiers in immunology · 2013Article
- B cells as effectors and regulators of sex-biased arthritis.Autoimmunity · 2012Review
- T cells as pioneers: antigen-specific T cells condition inflamed sites for high-rate antigen-non-specific effector cell recruitment.Immunology · 2009Article
- B cells are important as antigen presenting cells for induction of MHC-restricted arthritis in transgenic mice.Molecular immunology · 2007Article
- Skewed T-cell receptor BV14 and BV16 expression and shared CDR3 sequence and common sequence motifs in synovial T cells of rheumatoid arthritis.Genes and immunity · 2005Article
- Characterisation of T cell clonotypes that accumulated in multiple joints of patients with rheumatoid arthritis.Annals of the rheumatic diseases · 1999Article
- Heterogeneity of rheumatoid arthritis: from phenotypes to genotypes.Springer seminars in immunopathology · 1998Article
- Multiple mechanisms support oligoclonal T cell expansion in rheumatoid synovitis.Molecular medicine (Cambridge, Mass.) · 1997Article
- Myonuclear apoptosis in dystrophic mdx muscle occurs by perforin-mediated cytotoxicity.The Journal of clinical investigation · 1997Article
- T cell receptor biases and clonal proliferations among lung transplant recipients with obliterative bronchiolitis.The Journal of clinical investigation · 1996Article
- Cytolytic T lymphocyte responses of cancer patients to tumor-associated antigens.Springer seminars in immunopathology · 1996Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Identification of expanded clones engaged in immune and autoimmune responses is still imperfect, since they are often diluted by irrelevant cells expressing diverse specificities. To efficiently characterize T cell receptors expressed by clonally expanded lymphocytes in rheumatoid arthritis (RA) and other inflammatory conditions, we developed an assay system, termed sequence enrichment nuclease assay (SENA). Key elements of SENA are the efficiency of heat-denatured DNA strand reassociation, which increases exponentially with concentration, and the elimination of unhybridized sequences by single-strand-specific DNase. T cell clonal expansions were identified primarily in synovial fluids, but also in peripheral blood of RA patients. Synovial fluids had more prominent expansions in the CD8 than the CD4 subset, whereas clonal expansions in the CD4 subset predominated among peripheral blood lymphocytes. Dominant clones exhibited diverse sequences with no clear conservation of junctional motifs, although the same amino acid sequence was identified in two patients. In most instances, dominant clones in the blood were discordant to those in the corresponding synovial fluid, suggesting local stimulation or preferential sequestration of T cells displaying particular specifities.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.