ArticleThe Journal of clinical investigation1996
Molecular determinants of acute inflammatory responses to biomaterials.
Article in The Journal of clinical investigation, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 208 citations in OpenAlex.
- Cytokines as biomarkers of inflammatory response after open versus endovascular repair of abdominal aortic aneurysms: a systematic review.Acta pharmacologica Sinica · 2018Pooled it
- Histamine release and fibrinogen adsorption mediate acute inflammatory responses to biomaterial implants in humans.Journal of translational medicine · 2007Trial
- A central role for fibrinogen in promoting microglial repair of the hypoxia-disrupted blood-brain barrier.Journal of neuroinflammation · 2026Article
- Silicone implant surface microtopography modulates inflammation and tissue repair in capsular fibrosis.Frontiers in immunology · 2024Article
- Fibrin polymer on the surface of biomaterial implants drives the foreign body reaction.Biomaterials · 2021Article
- Fibers Generated by Plasma Des-AA Fibrin Monomers and Protofibril/Fibrinogen Clusters Bind Platelets: Clinical and Nonclinical Implications.TH open : companion journal to thrombosis and haemostasis · 2021Article
- Domesticating the foreign body response: Recent advances and applications.Advanced drug delivery reviews · 2019Review
- Surgical perspectives regarding application of biomaterials for the management of large congenital diaphragmatic hernia defects.Pediatric surgery international · 2018Review
- Inhibition of the cluster of differentiation 14 innate immunity pathway with IAXO-101 improves chronic microelectrode performance.Journal of neural engineering · 2018Article
- Changes in chemical and ultrastructural composition of ameroid constrictors following in vitro expansion.PloS one · 2018Article
- Analysis of theBioactive materials · 2017Article
- Past, Present and Future of Surgical Meshes: A Review.Membranes · 2017Review
- Distinct Effects of Integrins αXβ2 and αMβ2 on Leukocyte Subpopulations during Inflammation and Antimicrobial Responses.Infection and immunity · 2017Article
- The Internal Dynamics of Fibrinogen and Its Implications for Coagulation and Adsorption.PLoS computational biology · 2015Article
- Effects of nanoporous alumina on inflammatory cell response.Journal of biomedical materials research. Part A · 2014Article
- Integrin-directed modulation of macrophage responses to biomaterials.Biomaterials · 2014Article
- Optical imaging of fibrin deposition to elucidate participation of mast cells in foreign body responses.Biomaterials · 2014Article
- Concept of the aortic aneurysm repair-related surgical stress: a review of the literature.International journal of clinical and experimental medicine · 2014Review
- Article
- Adsorbed fibrinogen enhances production of bone- and angiogenic-related factors by monocytes/macrophages.Tissue engineering. Part A · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The frequent inflammatory responses to implanted medical devices are puzzling in view of the inert and nontoxic nature of most biomaterials. Because implant surfaces spontaneously adsorb host proteins, this proteinaceous film is probably important in the subsequent attraction of phagocytes. In fact, earlier we found that acute inflammatory responses to experimental polyethylene terephthalate implants in mice require the precedent adsorption of one particular host protein, fibrinogen. The present investigations were aimed at defining the molecular determinants of fibrinogen-mediated acute inflammatory responses to implanted biomaterials. We find: (a) plasmin degradation of purified fibrinogen into defined domains reveals that the proinflammatory activity resides within the D fragment, which contains neither the fibrin cross-linking sites nor RGD sequences; (b) the major (and, perhaps, exclusive) proinflammatory sequence appears to be fibrinogen gamma 190-202, previously shown to interact with CD11b/CD18 (Mac-1). The chemically synthesized peptide, cross-linked to albumin (which itself does not promote inflammatory responses), mimics the proinflammatory effect of adsorbed native fibrinogen; and (c) this sequence probably promotes inflammatory responses through interactions with Mac-1 because phagocyte accumulation on experimental implants is almost completely abrogated by administration of recombinant neutrophil inhibitory factor (which blocks CD11b-fibrin(ogen) interaction). We conclude that improved knowledge of such surface-protein-phagocyte interactions may permit the future development of more biocompatible implantable materials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.