ArticleThe Journal of cell biology1996
Neuroglian-mediated cell adhesion induces assembly of the membrane skeleton at cell contact sites.
Article in The Journal of cell biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 126 citations in OpenAlex.
- Transcriptomic analysis of feminizing somatic stem cells in the Drosophila testis reveals putative downstream effectors of the transcription factor Chinmo.G3 (Bethesda, Md.) · 2021Article
- Glial and Neuronal Neuroglian, Semaphorin-1a and Plexin A Regulate Morphological and Functional Differentiation ofFrontiers in endocrinology · 2021Article
- Collectively stabilizing and orienting posterior migratory forces disperses cell clusters in vivo.Nature communications · 2020Article
- Optimized expression of the antimicrobial protein Gloverin from Galleria mellonella using stably transformed Drosophila melanogaster S2 cells.Cytotechnology · 2017Article
- L1CAM/Neuroglian controls the axon-axon interactions establishing layered and lobular mushroom body architecture.The Journal of cell biology · 2015Article
- Genetic studies of spectrin in the larval fat body of Drosophila melanogaster: evidence for a novel lipid uptake apparatus.Genetics · 2013Article
- Transsynaptic coordination of synaptic growth, function, and stability by the L1-type CAM Neuroglian.PLoS biology · 2013Article
- Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation.Human molecular genetics · 2011Article
- The Drosophila L1CAM homolog Neuroglian signals through distinct pathways to control different aspects of mushroom body axon development.Development (Cambridge, England) · 2011Article
- Proteolysis of submembrane cytoskeletal proteins ankyrin-G and αII-spectrin following diffuse brain injury: a role in white matter vulnerability at Nodes of Ranvier.Brain pathology (Zurich, Switzerland) · 2010Article
- The spectrin-ankyrin-4.1-adducin membrane skeleton: adapting eukaryotic cells to the demands of animal life.Protoplasma · 2010Review
- The Drosophila Anion Exchanger (DAE) lacks a detectable interaction with the spectrin cytoskeleton.Journal of negative results in biomedicine · 2010Article
- Article
- The interaction between L1-type proteins and ankyrins--a master switch for L1-type CAM function.Cellular & molecular biology letters · 2009Review
- The lateral mobility of cell adhesion molecules is highly restricted at septate junctions in Drosophila.BMC cell biology · 2008Article
- Drosophila as a genetic and cellular model for studies on axonal growth.Neural development · 2007Review
- A postsynaptic spectrin scaffold defines active zone size, spacing, and efficacy at the Drosophila neuromuscular junction.The Journal of cell biology · 2006Article
- Activation of epidermal growth factor receptor mediates receptor axon sorting and extension in the developing olfactory system of the moth Manduca sexta.The Journal of comparative neurology · 2006Article
- Axonal ensheathment and septate junction formation in the peripheral nervous system of Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Functional links between membrane transport and the spectrin cytoskeleton.The Journal of membrane biology · 2006Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The protein ankyrin links integral membrane proteins to the spectrin-based membrane skeleton. Ankyrin is often concentrated within restricted membrane domains of polarized epithelia and neurons, but the mechanisms responsible for membrane targeting and its segregation within a continuous lipid bilayer remain unexplained. We provide evidence that neuroglian, a cell adhesion molecule related to L1 and neurofascin, can transmit positional information directly to ankyrin and thereby polarize its distribution in Drosophila S2 tissue culture cells. Ankyrin was not normally associated with the plasma membrane of these cells. Upon expression of an inducible neuroglian minigene, however, cells aggregated into large clusters and ankyrin became concentrated at sites of cell-cell contact. Spectrin was also recruited to sites of cell contact in response to neuroglian expression. The accumulation of ankyrin at cell contacts required the presence of the cytoplasmic domain of neuroglian since a glycosyl phosphatidylinositol-linked form of neuroglian failed to recruit ankyrin to sites of cell-cell contact. Double-labeling experiments revealed that, whereas ankyrin was strictly associated with sites of cell-cell contact, neuroglian was more broadly distributed over the cell surface. A direct interaction between neuroglian and ankyrin was demonstrated using yeast two-hybrid analysis. Thus, neuroglian appears to be activated by extracellular adhesion so that ankyrin and the membrane skeleton selectively associate with sites of cell contact and not with other regions of the plasma membrane.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.