ArticleThe EMBO journal1996
Cytoplasmic retention and nuclear import of 5S ribosomal RNA containing RNPs.
Article in The EMBO journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 57 citations in OpenAlex.
- A nuclear import pathway exploited by pathogenic noncoding RNAs.The Plant cell · 2022Article
- Studies on Viroid Shed Light on the Role of RNA Three-Dimensional Structural Motifs in RNA Trafficking in Plants.Frontiers in plant science · 2022Review
- Nuclear import receptors and hnRNPK mediates nuclear import and stress granule localization of SIRLOIN.Cellular and molecular life sciences : CMLS · 2021Article
- Extraribosomal Functions of Cytosolic Ribosomal Proteins in Plants.Frontiers in plant science · 2021Review
- Mitochondrial noncoding RNA transport.BMB reports · 2017Review
- Biological significance of 5S rRNA import into human mitochondria: role of ribosomal protein MRP-L18.Genes & development · 2011Article
- Mitochondrial enzyme rhodanese is essential for 5 S ribosomal RNA import into human mitochondria.The Journal of biological chemistry · 2010Article
- Participation of Xenopus Elr-type proteins in vegetal mRNA localization during oogenesis.The Journal of biological chemistry · 2009Article
- Two distinct structural elements of 5S rRNA are needed for its import into human mitochondria.RNA (New York, N.Y.) · 2008Article
- Identification and characterization of transcription factor IIIA and ribosomal protein L5 from Arabidopsis thaliana.Nucleic acids research · 2003Article
- The participation of 5S rRNA in the co-translational formation of a eukaryotic 5S ribonucleoprotein complex.Nucleic acids research · 2001Article
- RNA-dependent cytoplasmic anchoring of a transcription factor subunit during Xenopus development.The EMBO journal · 2000Article
- Assembly of 5S ribosomal RNA is required at a specific step of the pre-rRNA processing pathway.The Journal of cell biology · 1999Article
- Ribonucleoprotein particles of quiescent maize embryonic axes.Plant molecular biology · 1998Article
- Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.The EMBO journal · 1998Article
- A nuclear export signal is essential for the cytosolic localization of the Ran binding protein, RanBP1.The Journal of cell biology · 1996Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nuclear export of newly transcribed 5S ribosomal RNA in Xenopus oocytes occurs in the context of either a complex with the ribosomal protein L5 (5S RNP) or with the transcription factor IIIA (7S RNP). Here we examine nuclear import of 5S RNA, L5 and TFIIIA. The 5S RNP shuttles between nucleus and cytoplasm and only 5S RNA variants which can bind to L5 gain access to the nucleus. The 7S RNP is retained in the cytoplasm. Only TFIIIA which is not bound to 5S RNA is imported into the nucleus. As a novel mechanism for cytoplasmic retention, we propose that RNA binding masks a nuclear localization sequence in TFIIIA. In contrast to the nuclear import of L5, import of TFIIIA is sensitive towards the nuclear localization sequence (NLS) competitor p(lys)-BSA, suggesting that these two proteins make use of different import pathways.
Indexed as
Identifiers
8635471PMC450043W156619880What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.