ArticleThe EMBO journal1996
Crystal structure of the RNA binding ribosomal protein L1 from Thermus thermophilus.
Article in The EMBO journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 83 citations in OpenAlex.
- RAPDOR: Using Jensen-Shannon Distance for the computational analysis of complex proteomics datasets.Nature communications · 2025Article
- Protein Fold Usages in Ribosomes: Another Glance to the Past.International journal of molecular sciences · 2024Article
- Extraribosomal Functions of Bacterial Ribosomal Proteins-An Update, 2023.International journal of molecular sciences · 2024Review
- Studying the properties of domain I of the ribosomal protein l1: incorporation into ribosome and regulation of the l1 operon expression.The protein journal · 2015Article
- Functional Importance of Mobile Ribosomal Proteins.BioMed research international · 2015Review
- The role of L1 stalk-tRNA interaction in the ribosome elongation cycle.Journal of molecular biology · 2010Article
- Interactions of an essential Bacillus subtilis GTPase, YsxC, with ribosomes.Journal of bacteriology · 2008Article
- The RAGNYA fold: a novel fold with multiple topological variants found in functionally diverse nucleic acid, nucleotide and peptide-binding proteins.Nucleic acids research · 2007Article
- RNA chaperone activity of L1 ribosomal proteins: phylogenetic conservation and splicing inhibition.Nucleic acids research · 2007Article
- Domain I of ribosomal protein L1 is sufficient for specific RNA binding.Nucleic acids research · 2007Article
- Ribosomal protein L1 recognizes the same specific structural motif in its target sites on the autoregulatory mRNA and 23S rRNA.Nucleic acids research · 2005Article
- RNA chaperone activity of large ribosomal subunit proteins from Escherichia coli.RNA (New York, N.Y.) · 2004Article
- Phylogenetic analysis of the rplA genes encoding ribosomal protein L1.Folia microbiologica · 2001Article
- Magnesium ions mediate contacts between phosphoryl oxygens at positions 2122 and 2176 of the 23S rRNA and ribosomal protein L1.RNA (New York, N.Y.) · 2000Article
- The bacterial cell-division protein ZipA and its interaction with an FtsZ fragment revealed by X-ray crystallography.The EMBO journal · 2000Article
- Crystal structure of ribosomal protein L4 shows RNA-binding sites for ribosome incorporation and feedback control of the S10 operon.The EMBO journal · 2000Article
- The crystal structure of ribosomal protein S4 reveals a two-domain molecule with an extensive RNA-binding surface: one domain shows structural homology to the ETS DNA-binding motif.The EMBO journal · 1998Article
- Precise determination of RNA-protein contact sites in the 50 S ribosomal subunit of Escherichia coli.The Biochemical journal · 1998Article
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
L1 has a dual function as a ribosomal protein binding rRNA and as a translational repressor binding mRNA. The crystal structure of L1 from Thermus thermophilus has been determined at 1.85 angstroms resolution. The protein is composed of two domains with the N- and C-termini in domain I. The eight N-terminal residues are very flexible, as the quality of electron density map shows. Proteolysis experiments have shown that the N-terminal tail is accessible and important for 23S rRNA binding. Most of the conserved amino acids are situated at the interface between the two domains. They probably form the specific RNA binding site of L1. Limited non-covalent contacts between the domains indicate an unstable domain interaction in the present conformation. Domain flexibility and RNA binding by induced fit seems plausible.
Indexed as
Identifiers
8635468PMC450039W143946901What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.