ArticleThe EMBO journal1996
Lack of Drosophila cytoskeletal tropomyosin affects head morphogenesis and the accumulation of oskar mRNA required for germ cell formation.
Article in The EMBO journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 80 citations in OpenAlex.
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- Comparative Proteomic Profiling Reveals Molecular Characteristics Associated with Oogenesis and Oocyte Maturation during Ovarian Development of Bactrocera dorsalis (Hendel).International journal of molecular sciences · 2017Article
- A new isoform of Drosophila non-muscle Tropomyosin 1 interacts with Kinesin-1 and functions in oskar mRNA localization.Journal of cell science · 2016Article
- A novel tropomyosin isoform functions at the mitotic spindle and Golgi in Drosophila.Molecular biology of the cell · 2015Article
- DAAM is required for thin filament formation and Sarcomerogenesis during muscle development in Drosophila.PLoS genetics · 2014Article
- Fine scale analysis of gene expression in Drosophila melanogaster gonads reveals Programmed cell death 4 promotes the differentiation of female germline stem cells.BMC developmental biology · 2012Article
- Tropomyosin is an interaction partner of the Drosophila coiled coil protein yuri gagarin.Experimental cell research · 2011Article
- Functional identity of the gamma tropomyosin gene: Implications for embryonic development, reproduction and cell viability.Bioarchitecture · 2011Article
- Orientation of microtubules suggests a role in mRNA transportation in fertilized eggs of Chinese pine (Pinus tabulaeformis).Protoplasma · 2007Article
- Drosophila starvin encodes a tissue-specific BAG-domain protein required for larval food uptake.Genetics · 2005Article
- The essential role of PP1beta in Drosophila is to regulate nonmuscle myosin.Molecular biology of the cell · 2004Article
- Gamma tropomyosin gene products are required for embryonic development.Molecular and cellular biology · 2004Article
- Roles of Bifocal, Homer, and F-actin in anchoring Oskar to the posterior cortex of Drosophila oocytes.Genes & development · 2004Article
- Targeting of a tropomyosin isoform to short microfilaments associated with the Golgi complex.Molecular biology of the cell · 2004Article
- Green fluorescent protein tagging Drosophila proteins at their native genomic loci with small P elements.Genetics · 2003Article
- Genetic modifier screens in Drosophila demonstrate a role for Rho1 signaling in ecdysone-triggered imaginal disc morphogenesis.Genetics · 2003Article
- Actin filament-stabilizing protein tropomyosin regulates the size of dendritic fields.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Barentsz, a new component of the Staufen-containing ribonucleoprotein particles in mammalian cells, interacts with Staufen in an RNA-dependent manner.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drosophila encodes five muscle and one cytoskeletal isoform of the actin-binding protein tropomyosin. We have identified a lack-of-function mutation in the cytoskeletal isoform (cTmII). Zygotic mutant embryos show a defect in head morphogenesis, while embryos lacking maternal cTmII are defective in germ cell formation but otherwise give rise to viable adults. oskar mRNA, which is required for both germ cell formation and abdominal segmentation, fails to accumulate at the posterior pole in these embryos. nanos mRNA, however, which is required exclusively for abdominal segmentation, is localized at wild-type levels. These results indicate that head morphogenesis and the accumulation of high levels of oskar mRNA necessary for germ cell formation require tropomyosin-dependent cytoskeleton.
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8635457PMC450027W1491848067What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.