Evidence map›Paper›PMID 8634618›Full record

ArticleBMJ (Clinical research ed.)1996

What can be concluded from the Oxcheck and British family heart studies: commentary on cost effectiveness analyses.

D Wonderling, S Langham, M Buxton, C Normand, C McDermott

Abstract readComment
In one paragraph

Article in BMJ (Clinical research ed.), 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  7. The validity of dietary assessment in general practice.Journal of epidemiology and community health · 1999
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  17. Is population coronary heart disease risk screening justified? A discussion of the National Service Framework for coronary heart disease (Standard 4).The British journal of general practice : the journal of the Royal College of General Practitioners · 2001
    Article
  18. Preventing cardiovascular disease in primary care.BMJ (Clinical research ed.) · 2001
    Article
  19. Article
  20. Can dietary assessment in general practice target patients with unhealthy diets?The British journal of general practice : the journal of the Royal College of General Practitioners · 2000
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

D WonderlingHealth Economics Research Group, Brunel University, Uxbridge, Middlesex.
S Langham
M Buxton
C Normand
C McDermott

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo provide a commentary on the economic evaluations of the Oxcheck and British family heart studies: direct comparison of their relative effectiveness and cost effectiveness; comparisons with other interventions; and consideration of problems encountered.

designModelling from cost and effectiveness data to estimate of cost per life year gained. SUBJECTS: Middle aged men and women.

interventionsScreening for cardiovascular risk factors followed by appropriate lifestyle advice and drug intervention in general practice, and other primary coronary risk management strategies.

main outcome measuresLife years gained; cost per life year gained.

resultsDepending on the assumed duration of risk reduction, the programme cost per discounted life year gained ranged from 34,800 pounds for a 1 year duration to 1500 pounds for 20 years for the British family heart study and from 29,300 pounds to 900 pounds for Oxcheck. These figures exclude broader net clinical and cost effects and longer term clinical and cost effects other than coronary mortality.

conclusionsDespite differences in underlying methods, the estimates in the two economic analyses of the studies can be directly compared. Neither study was large enough to provide precise estimates of the overall net cost. Modelling to cost per life year gained provides more readily interpretable measures. These estimates emphasise the importance of the relatively weak evidence on duration effect. Only if the effect lasts at least five years is the Oxcheck programme likely to be cost effective. The effect must last for about 10 years to justify the extra cost associated with the British family heart study.

Indexed as

AdultCardiovascular DiseasesCoronary DiseaseCost-Benefit AnalysisCosts and Cost AnalysisEnglandFemaleHealth PolicyHealth PromotionHealth Services ResearchHumansMaleMass ScreeningMiddle AgedProgram EvaluationValue of Life

Identifiers

PMID8634618
PMCPMC2351093

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.