ArticleProceedings of the National Academy of Sciences of the United States of America1996
BCL2 regulates neural differentiation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 131 citations in OpenAlex.
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- The MAP Kinase Phosphatase MKP-1 Modulates Neurogenesis via Effects on BNIP3 and Autophagy.Biomolecules · 2021Article
- Stress Relief Techniques: p38 MAPK Determines the Balance of Cell Cycle and Apoptosis Pathways.Biomolecules · 2021Review
- Bcl-2 Overexpression Induces Neurite Outgrowth via the Bmp4/Tbx3/NeuroD1 Cascade in H19-7 Cells.Cellular and molecular neurobiology · 2020Article
- TNFα and IL-1β modify the miRNA cargo of astrocyte shed extracellular vesicles to regulate neurotrophic signaling in neurons.Cell death & disease · 2018Article
- Maternal deprivation alters expression of neural maturation gene tbr1 in the amygdala paralaminar nucleus in infant female macaques.Developmental psychobiology · 2017Article
- Characterization of Apoptosis Signaling Cascades During the Differentiation Process of Human Neural ReNcell VM Progenitor Cells In Vitro.Cellular and molecular neurobiology · 2015Article
- Ethanol upregulates NMDA receptor subunit gene expression in human embryonic stem cell-derived cortical neurons.PloS one · 2015Article
- Phospholipase D1 increases Bcl-2 expression during neuronal differentiation of rat neural stem cells.Molecular neurobiology · 2015Article
- Telencephalin protects PAJU cells from amyloid beta protein-induced apoptosis by activating the ezrin/radixin/moesin protein family/phosphatidylinositol-3-kinase/protein kinase B pathway.Neural regeneration research · 2012Article
- Driving apoptosis-relevant proteins toward neural differentiation.Molecular neurobiology · 2012Review
- Insulin promotes neuronal survival via the alternatively spliced protein kinase CδII isoform.The Journal of biological chemistry · 2012Article
- Phosphorylation and subcellular localization of p27Kip1 regulated by hydrogen peroxide modulation in cancer cells.PloS one · 2012Article
- Where and what is the paralaminar nucleus? A review on a unique and frequently overlooked area of the primate amygdala.Neuroscience and biobehavioral reviews · 2012Review
- Heterogeneous intrastriatal pattern of proteins regulating axon growth in normal adult human brain.Neurobiology of disease · 2011Article
- Apoptosis-associated microRNAs are modulated in mouse, rat and human neural differentiation.BMC genomics · 2010Article
- In vitro and in vivo enhanced generation of human A9 dopamine neurons from neural stem cells by Bcl-XL.The Journal of biological chemistry · 2010Article
- Trophic factors and stem cells for promoting recovery in stroke.Journal of vascular and interventional neurology · 2010Article
- Article
- Bcl2 enhances induced hematopoietic differentiation of murine embryonic stem cells.Experimental hematology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A main function attributed to the BCL2 protein is its ability to confer resistance against apoptosis. In addition to the constitutively high expression of BCL2, caused by gene rearrangement in follicular lymphomas, elevated expression of the BCL2 gene has been found in differentiating hematopoietic, neural, and epithelial tissues. To address the question of whether the expression of BCL2 is a cause or consequence of cell differentiation, we used a human neural-crest-derived tumor cell line, Paju, that undergoes spontaneous neural differentiation in vitro. The Paju cell line displays moderate expression of BCL2, the level of which increases in parallel with further neural differentiation induced by treatment with phorbol 12-myristate 13-acetate. Transfection of normal human BCL2 cDNA in sense and antisense orientations had a dramatic impact on the differentiation of the Paju cells. Overexpression of BCL2 cDNA induced extensive neurite outgrowth, even in low serum concentrations, together with an increased expression of neuron-specific enolase. Paju cells expressing the anti-sense BCL2 cDNA construct, which reduced the endogenous levels of BCL2, did not undergo spontaneous neural differentiation. These cells acquired an epithelioid morphology and up-regulated the intermediate filament protein nestin, typically present in primitive neuroectodermal cells. The manipulated levels of BCL2 did not have appreciable impact on cell survival in normal culture. Our findings demonstrate that the BCL2 gene product participates in the regulation of neural differentiation.
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