ArticleProceedings of the National Academy of Sciences of the United States of America1996
Chromogranin B (secretogranin I) promotes sorting to the regulated secretory pathway of processing intermediates derived from a peptide hormone precursor.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 125 citations in OpenAlex.
- Protein condensates in the the secretory pathway: Unraveling biophysical interactions and function.Biophysical journal · 2024Review
- Peptidomic Analysis Reveals Seasonal Neuropeptide and Peptide Hormone Changes in the Hypothalamus and Pituitary of a Hibernating Mammal.ACS chemical neuroscience · 2023Article
- Forty years of the adrenal chromaffin cell through ISCCB meetings around the world.Pflugers Archiv : European journal of physiology · 2023Review
- Cell-specific secretory granule sorting mechanisms: the role of MAGEL2 and retromer in hypothalamic regulated secretion.Frontiers in cell and developmental biology · 2023Review
- Liquid-liquid phase separation facilitates the biogenesis of secretory storage granules.The Journal of cell biology · 2022Article
- Short-Term Administration of Common Anesthetics Does Not Dramatically Change the Endogenous Peptide Profile in the Rat Pituitary.ACS chemical neuroscience · 2022Article
- Nutrient Regulation of Pancreatic Islet β-Cell Secretory Capacity and Insulin Production.Biomolecules · 2022Review
- Performance Evaluation of the KRYPTOR Compact PLUS Analyzer-Based B.R.A.H.M.S. CgA Ⅱ KRYPTOR Assay for Chromogranin A Measurement.Diagnostics (Basel, Switzerland) · 2021Article
- Inside the Insulin Secretory Granule.Metabolites · 2021Review
- Chromogranin B regulates early-stage insulin granule trafficking from the Golgi in pancreatic islet β-cells.Journal of cell science · 2019Article
- Dense-core vesicle biogenesis and exocytosis in neurons lacking chromogranins A and B.Journal of neurochemistry · 2018Article
- A systems approach identifies co-signaling molecules of early growth response 1 transcription factor in immobilization stress.BMC systems biology · 2014Article
- The granin VGF promotes genesis of secretory vesicles, and regulates circulating catecholamine levels and blood pressure.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- Chromogranin B: intra- and extra-cellular mechanisms to regulate catecholamine storage and release, in catecholaminergic cells and organisms.Journal of neurochemistry · 2014Article
- The functional role of chromogranins in exocytosis.Journal of molecular neuroscience : MN · 2012Article
- Stress triggered changes in expression of genes for neurosecretory granules in adrenal medulla.Cellular and molecular neurobiology · 2012Article
- Forward targeting of Toxoplasma gondii proproteins to the micronemes involves conserved aliphatic amino acids.Traffic (Copenhagen, Denmark) · 2011Article
- Reprint of: Chromogranin A: a new proposal for trafficking, processing and induction of granule biogenesis.Regulatory peptides · 2010Article
- Chromogranins A and B as regulators of vesicle cargo and exocytosis.Cellular and molecular neurobiology · 2010Review
- Chromogranin A: a new proposal for trafficking, processing and induction of granule biogenesis.Regulatory peptides · 2010Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chromogranin B (CgB, secretogranin I) is a widespread constituent of neuroendocrine secretory granules whose function is unknown. To determine whether CgB affects the sorting of peptide hormone and neuropeptide precursors to secretory granules, we overexpressed CgB in AtT-20 cells, which exhibit an only moderate capacity to sort proopiomelanocortin and proteolytic fragments derived therefrom. In mock-transfected AtT-20 cells, a substantial proportion of newly synthesized proopiomelanocortin and its two primary proteolytic products generated in the trans-Golgi network, the N-terminal 23-kDa fragment containing adrenocorticotropin and the C-terminal beta-lipotropin fragment, was secreted via the constitutive pathway. Two- to three-fold overexpression of CgB markedly reduced the constitutive secretion of the 23-kDa fragment, but not beta-lipotropin and tripled the amount of adrenocorticotropin generated and stored in secretory granules. Our results indicate the existence of neuroendocrine-specific helper proteins which promote the sorting from the trans-Golgi network to secretory granules of certain processing intermediates derived from peptide hormone and neuropeptide precursors and demonstrate that CgB functions as such.
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