ArticleProceedings of the National Academy of Sciences of the United States of America1996
Modulation of promoter occupancy by cooperative DNA binding and activation-domain function is a major determinant of transcriptional regulation by activators in vivo.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The ATF6-Met[67]Val substitution is associated with increased plasma cholesterol levels.Arteriosclerosis, thrombosis, and vascular biology · 2009Pooled it
- Review
- ATF6 as a Nodal Regulator of Proteostasis in the Heart.Frontiers in physiology · 2020Review
- Role of integrative structural biology in understanding transcriptional initiation.Methods (San Diego, Calif.) · 2019Review
- Carboxypeptidase E, Identified As a Direct Interactor of Growth Hormone, Is Important for Efficient Secretion of the Hormone.Molecules and cells · 2016Article
- Spatial promoter recognition signatures may enhance transcription factor specificity in yeast.PloS one · 2013Article
- Structural constraints in collaborative competition of transcription factors against the nucleosome.Journal of molecular biology · 2011Article
- From DNA sequence to transcriptional behaviour: a quantitative approach.Nature reviews. Genetics · 2009Review
- Probing intrinsic properties of a robust morphogen gradient in Drosophila.Developmental cell · 2008Article
- Artificial recruitment of mediator by the DNA-binding domain of Adr1 overcomes glucose repression of ADH2 expression.Molecular and cellular biology · 2008Article
- Single-molecule and population probing of chromatin structure using DNA methyltransferases.Methods (San Diego, Calif.) · 2007Article
- Regulation of the endogenous VEGF-A gene by exogenous designed regulatory proteins.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Article
- Specificity and regulation of DNA binding by the yeast glucose transporter gene repressor Rgt1.Molecular and cellular biology · 2003Article
- Enhancer sequences influence the role of the amino-terminal domain of bicoid in transcription.Molecular and cellular biology · 2003Article
- Regions of GAL4 critical for binding to a promoter in vivo revealed by a visual DNA-binding analysis.The EMBO journal · 2003Article
- Collaborative competition mechanism for gene activation in vivo.Molecular and cellular biology · 2003Article
- GCN5 dependence of chromatin remodeling and transcriptional activation by the GAL4 and VP16 activation domains in budding yeast.Molecular and cellular biology · 2001Article
- LexA chimeras reveal the function of Drosophila Fos as a context-dependent transcriptional activator.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Functional overlap of sequences that activate transcription and signal ubiquitin-mediated proteolysis.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Binding of transcriptional activators to a promoter is a prerequisite process in transcriptional activation. It is well established that the efficiency of activator binding to a promoter is determined by the affinity of direct interactions between the DNA-binding domain of an activator and its specific target sequences. However, I describe here that activator binding to a promoter is augmented in vivo by the effects of two other determinants that have not been generally appreciated: (i) the number of activator binding sites present in a promoter and (ii) the potency of activation domains of activators. Multiple sites within a promoter can cooperatively recruit cognate factors regardless of whether they contain an effective activation domain. This cooperativity can result in the synergistic activation of transcription. The second effect is the enhancement of activator binding to a promoter by the presence of activation domains. In this case, activation domains are not simply tethered to the promoter by the DNA-binding domain but instead assist the DNA-binding domain being tethered onto the promoter. This effect of activation domains on DNA binding is instrumental in determining how potent activators can induce steep transcriptional increases at low concentrations.
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