ArticleProceedings of the National Academy of Sciences of the United States of America1996
Serotonergic modulation of muscle acetylcholine receptors of different subunit composition.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 27 citations in OpenAlex.
- Methylpiperidinium Iodides as Novel Antagonists for α7 Nicotinic Acetylcholine Receptors.Frontiers in pharmacology · 2018Article
- Dopamine and serotonin modulate human GABAρ1 receptors expressed in Xenopus laevis oocytes.ACS chemical neuroscience · 2012Article
- The acetylcholinesterase inhibitor BW284c51 is a potent blocker of Torpedo nicotinic AchRs incorporated into the Xenopus oocyte membrane.British journal of pharmacology · 2005Article
- Combined actions of zinc and fluoxetine on nicotinic acetylcholine receptors.The pharmacogenomics journal · 2004Article
- Antagonism of nicotinic acetylcholine receptors by inhibitors of monoamine uptake.Molecular psychiatry · 2001Article
- Activation of volume-regulated Cl(-) channels by ACh and ATP in Xenopus follicles.The Journal of physiology · 2000Article
- Modulation of nicotinic acetylcholine receptors by strychnine.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Neuronal nicotinic threonine-for-leucine 247 alpha7 mutant receptors show different gating kinetics when activated by acetylcholine or by the noncompetitive agonist 5-hydroxytryptamine.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Blockage of muscle and neuronal nicotinic acetylcholine receptors by fluoxetine (Prozac).Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Threonine-for-leucine mutation within domain M2 of the neuronal alpha(7) nicotinic receptor converts 5-hydroxytryptamine from antagonist to agonist.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Marine sponges as pharmacy.Marine biotechnology (New York, N.Y.)Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Modulation of muscle acetylcholine (AcCho) receptors (AcChoRs) by serotonin [5-hydroxytryptamine (5HT)] and other serotonergic compounds was studied in Xenopus laevis oocytes. Various combinations of alpha, beta, gamma, and delta subunit RNAs were injected into oocytes, and membrane currents elicited by AcCho were recorded under voltage clamp. Judging by the amplitudes of AcCho currents generated, the levels of functional receptor expression were: alpha beta gamma delta > alpha beta delta > alpha beta gamma > alpha gamma delta. The alpha beta gamma delta and alpha beta delta AcChoR Subtypes were strongly blocked by 5HT, whereas the alpha beta gamma receptor was blocked only slightly. The order of blocking potency of AcChoRs by 5HT was: alpha beta delta > alpha beta gamma delta > alpha beta gamma. 5HT receptor antagonists, such as methysergide and spiperone, were even more potent blockers of AcChoRs than 5HT but did not show much subunit selectivity. Blockage of alpha beta gamma delta and alpha beta delta receptors by 5HT was voltage-dependent, and the voltage dependence was abolished when the delta subunit was omitted. These findings may need to be taken into consideration when trying to elucidate the mode of action of many clinically important serotonergic compounds.
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