ArticleProceedings of the National Academy of Sciences of the United States of America1996
A rat genetic map constructed by representational difference analysis markers with suitability for large-scale typing.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Development of the arbitrarily primed-representational difference analysis method and chromosomal mapping of isolated high throughput rat genetic markers.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Linkage mapping of the Bra, Brb and Brg genes for rat protein phosphatase 2A 55 kDa B-regulatory subunit isotypes.Japanese journal of cancer research : Gann · 1998Article
- Positional cloning without a genome map: using 'Targeted RFLP Subtraction' to isolate dense markers tightly linked to the regA locus of Volvox carteri.Nucleic acids research · 1998Article
- Rat chromosome 1: regional localization of seven genes (Slc9a3, Srd5a1, Esr, Tcp1, Grik5, Tnnt3, Jak2) and anchoring of the genetic linkage map to the cytogenetic map.Mammalian genome : official journal of the International Mammalian Genome Society · 1997Article
- Linkage mapping of rat Rb1 gene on chromosome 15.Mammalian genome : official journal of the International Mammalian Genome Society · 1997Article
- Establishment of methylation-sensitive-representational difference analysis and isolation of hypo- and hypermethylated genomic fragments in mouse liver tumors.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Cloning of rat Brca2 and linkage mapping to chromosome 12.Mammalian genome : official journal of the International Mammalian Genome Society · 1997Article
- Linkage mapping of the rat Tp53 gene on chromosome 10.Mammalian genome : official journal of the International Mammalian Genome Society · 1996Article
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9 authors.
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Abstract
Representational difference analysis (RDA) was applied to isolate chromosomal markers in the rat. Four series of RDA [restriction enzymes, BamHI and HindIII; subtraction of ACI/N (ACI) amplicon from BUF/Nac (BUF) amplicon and vice versa] yielded 131 polymorphic markers; 125 of these markers were mapped to all chromosomes except for chromosome X. This was done by using a mapping panel of 105 ACI x BUF F2 rats. To complement the relative paucity of chromosomal markers in the rat, genetically directed RDA, which allows isolation of polymorphic markers in the specific chromosomal region, was performed. By changing the F2 driver-DNA allele frequency around the region, four markers were isolated from the D1Ncc1 locus. Twenty-five of 27 RDA markers were informative regarding the dot blot analysis of amplicons, hybridizing only with tester amplicons. Dot blot analysis at a high density per unit of area made it possible to process a large number of samples. Quantitative trait loci can now be mapped in the rat genome by processing a large number of samples with RDA markers and then by isolating markers close to the loci of interest by genetically directed RDA.
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