ArticleThe EMBO journal1996
B-type cyclins regulate G1 progression in fission yeast in opposition to the p25rum1 cdk inhibitor.
Article in The EMBO journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
- Capturing CDKs in action: Live-cell biosensors pioneer the new frontiers in cell cycle research.Cell structure and function · 2025Review
- Cyclin-dependent kinases: Masters of the eukaryotic universe.Wiley interdisciplinary reviews. RNA · 2023Review
- The Meiosis-Specific Crs1 Cyclin Is Required for Efficient S-Phase Progression and Stable Nuclear Architecture.International journal of molecular sciences · 2021Article
- The fission yeast S-phase cyclin Cig2 can drive mitosis.Genetics · 2021Article
- CDK Regulation of Meiosis: Lessons fromGenes · 2020Review
- Requirement of PP2A-B56iScience · 2020Article
- Cell cycle transcriptomics of Capsaspora provides insights into the evolution of cyclin-CDK machinery.PLoS genetics · 2020Article
- Protein Phosphatases in G1 Regulation.International journal of molecular sciences · 2020Review
- CDK contribution to DSB formation and recombination in fission yeast meiosis.PLoS genetics · 2019Article
- Cell cycle control by a minimal Cdk network.PLoS computational biology · 2015Article
- Pom1 and cell size homeostasis in fission yeast.Cell cycle (Georgetown, Tex.) · 2013Article
- The role of the RACK1 ortholog Cpc2p in modulating pheromone-induced cell cycle arrest in fission yeast.PloS one · 2013Article
- Article
- A higher-order generalized singular value decomposition for comparison of global mRNA expression from multiple organisms.PloS one · 2011Article
- Article
- A Cds1-mediated checkpoint protects the MBF activator Rep2 from ubiquitination by anaphase-promoting complex/cyclosome-Ste9 at S-phase arrest in fission yeast.Molecular and cellular biology · 2009Article
- Article
- Pathocycles: Ustilago maydis as a model to study the relationships between cell cycle and virulence in pathogenic fungi.Molecular genetics and genomics : MGG · 2006Review
- Spindle pole body duplication in fission yeast occurs at the G1/S boundary but maturation is blocked until exit from S by an event downstream of cdc10+.Molecular biology of the cell · 2004Article
- G(1)/S CDK is inhibited to restrain mitotic onset when DNA replication is blocked in fission yeast.The EMBO journal · 2002Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The onset of S phase in fission yeast is regulated at Start, the point of commitment to the mitotic cell cycle. The p34cdc2 kinase is essential for G1 progression past Start, but until now its regulation has been poorly understood. Here we show that the cig2/cyc17 B-type cyclin has an important role in G1 progression, and demonstrate that p34cdc2 kinase activity is periodically associated with cig2 in G1. Cells lacking cig2 are defective in G1 progression, and this is particularly clear in small cells that must regulate Start with respect to cell size. We also find that the cig1 B-type cyclin can promote G1 progression. Whilst p25rum1 can inhibit cig2/cdc2 activity in vitro, and may transiently inhibit this complex in vivo, cig1 is regulated independently of p25rum1. Since cig1/cdc2 kinase activity peaks in mitotic cells, and decreases after mitosis with similar kinetics to cdc13-associated kinase activity, we suggest that cig2 is likely to be the principal fission yeast G1 cyclin. cig2 protein levels accumulate in G1 cells, and we propose that p25rum1 may transiently inhibit cig2-associated p34cdc2 activity until the critical cell size required for Start is reached.
Indexed as
Identifiers
8631305PMC450282What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.